PD-1+Tregcells: a foe in cancer immunotherapy?

被引：31
作者：
Aksoylar, Halil-Ibrahim [1 ,2 ]
Boussiotis, Vassiliki A. [1 ,2 ]
机构：
[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Div Hematol Oncol, Boston, MA 02115 USA
[2] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02115 USA
来源：
NATURE IMMUNOLOGY | 2020年 / 21卷 / 11期
基金：
美国国家卫生研究院;
关键词：
IMMUNE TOLERANCE; DIFFERENTIATION;
D O I：
10.1038/s41590-020-0801-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The mechanisms that drive responses to PD-1-blocking immunotherapy in some but not all patients have been puzzling. A new study suggests that the balance of PD-1 expression levels between CD8(+)T cells and T(reg)cells might provide an answer.
引用
收藏
页码：1311 / 1312
页数：2
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