PD-1+Tregcells: a foe in cancer immunotherapy?

被引：34

作者：

Aksoylar, Halil-Ibrahim ^{[1
,2
]}

Boussiotis, Vassiliki A. ^{[1
,2
]}

机构：

[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Div Hematol Oncol, Boston, MA 02115 USA

[2] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02115 USA

来源：

NATURE IMMUNOLOGY | 2020年 / 21卷 / 11期

基金：

美国国家卫生研究院;

关键词：

IMMUNE TOLERANCE; DIFFERENTIATION;

D O I：

10.1038/s41590-020-0801-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mechanisms that drive responses to PD-1-blocking immunotherapy in some but not all patients have been puzzling. A new study suggests that the balance of PD-1 expression levels between CD8(+)T cells and T(reg)cells might provide an answer.

引用

页码：1311 / 1312

页数：2

共 12 条

[1] Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer [J].

Ali, Khaled ;

Soond, Dalya R. ;

Pineiro, Roberto ;

Hagemann, Thorsten ;

Pearce, Wayne ;

Lim, Ee Lyn ;

Bouabe, Hicham ;

Scudamore, Cheryl L. ;

Hancox, Timothy ;

Maecker, Heather ;

Friedman, Lori ;

Turner, Martin ;

Okkenhaug, Klaus ;

Vanhaesebroeck, Bart .

NATURE, 2014, 510 (7505) :407-+

[2] The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment [J].

Delgoffe, Greg M. ;

Kole, Thomas P. ;

Zheng, Yan ;

Zarek, Paul E. ;

Matthews, Krystal L. ;

Xiao, Bo ;

Worley, Paul F. ;

Kozma, Sara C. ;

Powell, Jonathan D. .

IMMUNITY, 2009, 30 (06) :832-844

[3] Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway [J].

Fife, Brian T. ;

Guleria, Indira ;

Bupp, Melanie Gubbels ;

Eagar, Todd N. ;

Tang, Qizhi ;

Bour-Jordan, Helene ;

Yagita, Hideo ;

Azuma, Miyuki ;

Sayegh, Mohamed H. ;

Bluestone, Jeffrey A. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (12) :2737-2747

[4] PD-L1 regulates the development, maintenance, and function of induced regulatory T cells [J].

Francisco, Loise M. ;

Salinas, Victor H. ;

Brown, Keturah E. ;

Vanguri, Vijay K. ;

Freeman, Gordon J. ;

Kuchroo, Vijay K. ;

Sharpe, Arlene H. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (13) :3015-3029

[5] The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells [J].

Haxhinasto, Sokol ;

Mathis, Diane ;

Benoist, Christophe .

JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (03) :565-574

[6] Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors [J].

Hsieh, CS ;

Liang, YQ ;

Tyznik, AJ ;

Self, SG ;

Liggitt, D ;

Rudensky, AY .

IMMUNITY, 2004, 21 (02) :267-277

[7] The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies [J].

Kumagai, Shogo ;

Togashi, Yosuke ;

Kamada, Takahiro ;

Sugiyama, Eri ;

Nishinakamura, Hitomi ;

Takeuchi, Yoshiko ;

Vitaly, Kochin ;

Itahashi, Kota ;

Maeda, Yuka ;

Matsui, Shigeyuki ;

Shibahara, Takuma ;

Yamashita, Yasuho ;

Irie, Takuma ;

Tsuge, Ayaka ;

Fukuoka, Shota ;

Kawazoe, Akihito ;

Udagawa, Hibiki ;

Kirita, Keisuke ;

Aokage, Keiju ;

Ishii, Genichiro ;

Kuwata, Takeshi ;

Nakama, Kenta ;

Kawazu, Masahito ;

Ueno, Toshihide ;

Yamazaki, Naoya ;

Goto, Koichi ;

Tsuboi, Masahiro ;

Mano, Hiroyuki ;

Doi, Toshihiko ;

Shitara, Kohei ;

Nishikawa, Hiroyoshi .

NATURE IMMUNOLOGY, 2020, 21 (11) :1346-+

[8] Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor [J].

Miyara, Makoto ;

Yoshioka, Yumiko ;

Kitoh, Akihiko ;

Shima, Tomoko ;

Wing, Kajsa ;

Niwa, Akira ;

Parizot, Christophe ;

Taflin, Cecile ;

Heike, Toshio ;

Valeyre, Dominique ;

Mathian, Alexis ;

Nakahata, Tatsutoshi ;

Yamaguchi, Tomoyuki ;

Nomura, Takashi ;

Ono, Masahiro ;

Amoura, Zahir ;

Gorochov, Guy ;

Sakaguchi, Shimon .

IMMUNITY, 2009, 30 (06) :899-911

[9] PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation [J].

Patsoukis, Nikolaos ;

Bardhan, Kankana ;

Chatterjee, Pranam ;

Sari, Duygu ;

Liu, Bianling ;

Bell, Lauren N. ;

Karoly, Edward D. ;

Freeman, Gordon J. ;

Petkova, Victoria ;

Seth, Pankaj ;

Li, Lequn ;

Boussiotis, Vassiliki A. .

NATURE COMMUNICATIONS, 2015, 6

[10] HIF1α-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells [J].

Shi, Lewis Z. ;

Wang, Ruoning ;

Huang, Gonghua ;

Vogel, Peter ;

Neale, Geoffrey ;

Green, Douglas R. ;

Chi, Hongbo .

JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (07) :1367-1376

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