Hepatitis B virus genome variability and disease progression: the impact of pre-core mutants and HBV genotypes

被引：43

作者：

Buti, Maria ^{[1
]}

Rodriguez-Frias, Francisco ^{[1
]}

Jardi, Rosendo ^{[1
]}

Esteban, Rafael ^{[1
]}

机构：

[1] Hosp Gen Univ Vall dHebron, Liver Unit, Barcelona 08035, Spain

来源：

JOURNAL OF CLINICAL VIROLOGY | 2005年 / 34卷

关键词：

Hepatitis B; HBV genotype; Genome variability;

D O I：

10.1016/S1386-6532(05)80015-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The hepatitis B virus (HBV), a member of the Hepadnaviridae family, is prone to mutations due to its asymmetric replication via reverse transcription of an RNA intermediate. The estimated mutation rate of the hepadnavirus genome is >= 2 x 10(4) base substitutions/site/year. This mutation rate is approximately 100 times higher than that of other DNA viruses but between 100 and 1000 times lower than that of RNA viruses. Analyses of both naturally occurring viral variants and in vitro mutagenesis studies have identified some mutations that have a role in viral latency, pathogenesis of liver disease, immune escape, and resistance to axltiviral therapy. (C) 2005 Elsevier B.V. All rights reserved.

引用

页码：S79 / S82

页数：4

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