The CXCL16-CXCR6 chemokine axis in glial tumors

被引：33
作者：
Hattermann, Kirsten [1 ]
Held-Feindt, Janka [2 ]
Ludwig, Andreas [3 ]
Mentlein, Rolf [1 ]
机构：
[1] Univ Kiel, Dept Anat, D-24098 Kiel, Germany
[2] Univ Klinikum Schleswig Holstein, Dept Neurosurg, D-24105 Kiel, Germany
[3] Rhein Westfal TH Aachen, Interdisciplinary Ctr Clin Res, Inst Pharmacol & Toxicol, D-52074 Aachen, Germany
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2013年 / 260卷 / 1-2期
关键词：
Glioma; Astrocytoma; Chemokine; Receptor; Tumor stem cell; TRANSMEMBRANE CXC-CHEMOKINE; INITIATING CELLS; PROSTATE-CANCER; STEM-CELL; CHEMOTACTIC FACTOR; COLORECTAL-CANCER; GROWTH-FACTOR; HUMAN GLIOMAS; EXPRESSION; RECEPTOR;
D O I：
10.1016/j.jneuroim.2013.04.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Since chemokines and their receptors play a pivotal role in tumors, we investigated the CXCL16-CXCR6-axis in human astroglial tumors. The transmembrane chemokine CXCL16 is heavily expressed by tumor, microglial and endothelial cells in situ and in vitro. In contrast, the receptor CXCR6 is restricted in glioblastomas to a small subset of proliferating cells positive for the stem-cell markers Musashi, Nanog, Sox2 and Oct4. In particular, the vast majority (about 90%) of Musashi-positive cells stained also for CXCR6. Thus, CXCL16 is highly expressed by glial tumor and stroma cells whereas CXCR6 defines a subset of cells with stem cell character. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：47 / 54
页数：8
相关论文
共 44 条
[1]   The transmembrane CXC-chemokine ligand 16 is induced by IFN-γ and TNF-α and shed by the activity of the disintegrin-like metalloproteinase ADAM10 [J].
Abel, S ;
Hundhausen, C ;
Mentlein, R ;
Schulte, A ;
Berkhout, TA ;
Broadway, N ;
Hartmann, D ;
Sedlacek, R ;
Dietrich, S ;
Muetze, B ;
Schuster, B ;
Kallen, KJ ;
Saftig, P ;
Rose-John, S ;
Ludwig, A .
JOURNAL OF IMMUNOLOGY, 2004, 172 (10) :6362-6372
[2]   Glioblastoma cells: A heterogeneous and fatal tumor interacting with the parenchyma [J].
Alves, Tercia Rodrigues ;
Souza Lima, Flavia Regina ;
Kahn, Suzana Assad ;
Lobo, Denise ;
Feijo Dubois, Luiz Gustavo ;
Soletti, Rossana ;
Borges, Helena ;
Neto, Vivaldo Moura .
LIFE SCIENCES, 2011, 89 (15-16) :532-539
[3]   Enhanced Tumor Metastasis in Response to Blockade of the Chemokine Receptor CXCR6 Is Overcome by NKT Cell Activation [J].
Cullen, Robyn ;
Germanov, Elitza ;
Shimaoka, Takeshi ;
Johnston, Brent .
JOURNAL OF IMMUNOLOGY, 2009, 183 (09) :5807-5815
[4]   The Chemokine CXCL16 and Its Receptor, CXCR6, as Markers and Promoters of Inflammation-Associated Cancers [J].
Darash-Yahana, Merav ;
Gillespie, John W. ;
Hewitt, Stephen M. ;
Chen, Yun-Yun K. ;
Maeda, Shin ;
Stein, Ilan ;
Singh, Satya P. ;
Bedolla, Roble B. ;
Peled, Amnon ;
Troyer, Dean A. ;
Pikarsky, Eli ;
Karin, Michael ;
Farber, Joshua M. .
PLOS ONE, 2009, 4 (08)
[5]   Cancer stem cells and glioma [J].
Das, Sunit ;
Srikanth, Maya ;
Kessler, John A. .
NATURE CLINICAL PRACTICE NEUROLOGY, 2008, 4 (08) :427-435
[6]   Expression profile of embryonic stem cell-associated genes Oct4, Sox2 and Nanog in human gliomas [J].
Guo, Yuji ;
Liu, Shangming ;
Wang, Ping ;
Zhao, Shidou ;
Wang, Fuwu ;
Bing, Lujun ;
Zhang, Yanmin ;
Ling, Eng-Ang ;
Gao, Jiangang ;
Hao, Aijun .
HISTOPATHOLOGY, 2011, 59 (04) :763-775
[7]   Tumoural CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients [J].
Gutwein, Paul ;
Schramme, Anja ;
Sinke, Nina ;
Abdel-Bakky, Mohamed Sadek ;
Voss, Beren ;
Obermueller, Nicholas ;
Doberstein, Kai ;
Koziolek, Michael ;
Fritzsche, Florian ;
Johannsen, Manfred ;
Jung, Klaus ;
Schaider, Helmut ;
Alteuogt, Peter ;
Ludwig, Andreas ;
Pfeilschifter, Josef ;
Kristiansen, Glen .
EUROPEAN JOURNAL OF CANCER, 2009, 45 (03) :478-489
[8]   Clinical significance of CXCL16/CXCR6 expression in patients with prostate cancer [J].
Ha, Hong Koo ;
Lee, Wan ;
Park, Hyun Jun ;
Lee, Sang Don ;
Lee, Jeong Zoo ;
Chung, Moon Kee .
MOLECULAR MEDICINE REPORTS, 2011, 4 (03) :419-424
[9]   The chemokine CXCL16 induces migration and invasion of glial precursor cells via its receptor CXCR6 [J].
Hattermann, Kirsten ;
Ludwig, Andreas ;
Gieselmann, Volkmar ;
Held-Feindt, Janka ;
Mentlein, Rolf .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2008, 39 (01) :133-141
[10]   The Chemokine Receptor CXCR7 Is Highly Expressed in Human Glioma Cells and Mediates Antiapoptotic Effects [J].
Hattermann, Kirsten ;
Held-Feindt, Janka ;
Lucius, Ralph ;
Mueerkoester, Susanne Sebens ;
Penfold, Mark E. T. ;
Schall, Thomas J. ;
Mentlein, Rolf .
CANCER RESEARCH, 2010, 70 (08) :3299-3308
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