Probiotics in colorectal cancer (CRC) with emphasis on mechanisms of action and current perspectives

被引:95
作者
Kahouli, Imen [1 ,2 ,3 ,4 ,5 ]
Tomaro-Duchesneau, Catherine [1 ,2 ,3 ,4 ]
Prakash, Satya [1 ,2 ,3 ,4 ,5 ]
机构
[1] McGill Univ, Fac Med, Biomed Technol & Cell Therapy Res Lab, Dept Biomed Engn, Montreal, PQ H3A 2B4, Canada
[2] McGill Univ, Fac Med, Biomed Technol & Cell Therapy Res Lab, Dept Physiol, Montreal, PQ H3A 2B4, Canada
[3] McGill Univ, Fac Med, Biomed Technol & Cell Therapy Res Lab, Dept Artificial Cells, Montreal, PQ H3A 2B4, Canada
[4] McGill Univ, Fac Med, Organs Res Ctr, Montreal, PQ H3A 2B4, Canada
[5] McGill Univ, Fac Med, Div Expt Med, Montreal, PQ H3A 1A3, Canada
基金
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词
LACTIC-ACID BACTERIA; POSTOPERATIVE INFECTIOUS COMPLICATIONS; TIGHT JUNCTION PROTEINS; CHAIN FATTY-ACIDS; COLON-CANCER; IN-VIVO; GUT MICROBIOTA; FECAL WATER; EPITHELIAL BARRIER; DOUBLE-BLIND;
D O I
10.1099/jmm.0.048975-0
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Colorectal cancer (CRC) is the third most common form of cancer. Diverse therapies such as chemotherapy, immunotherapy and radiation have shown beneficial effects, but are limited because of their safety and toxicity. Probiotic formulations have shown great promise in CRC as preventive and early stage therapeutics. This review highlights the importance of a balanced intestinal microbiota and summarizes the recent developments in probiotics for treating CRC. Specifically, this report describes evidence of the role of probiotics in modulating the microbiota, in improving the physico-chemical conditions of the gut and in reducing oxidative stress. It also discusses the mechanisms of probiotics in inhibiting tumour progression, in producing anticancer compounds and in modulating the host immune response. Even though some of these effects were observed in several clinical trials, when probiotic formulations were used as a supplement to CRC therapies, the application of probiotics as biotherapeutics against CRC still needs further investigation.
引用
收藏
页码:1107 / 1123
页数:17
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