Quantitative Interpretation of Diffusion-Ordered NMR Spectra: Can We Rationalize Small Molecule Diffusion Coefficients?

被引：194

作者：

Evans, Robert ^{[1
]}

Deng, Zhaoxia ^{[1
]}

Rogerson, Alexandria K. ^{[1
]}

McLachlan, Andy S. ^{[3
]}

Richards, Jeff J. ^{[4
]}

Nilsson, Mathias ^{[1
,2
]}

Morris, Gareth A. ^{[1
]}

机构：

[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England

[2] Univ Copenhagen, Dept Food Sci, DK-1958 Frederiksberg C, Denmark

[3] Adv Chem Dev Inc, Toronto, ON, Canada

[4] GlaxoSmithKline, Brentford TW89GS, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 11期

基金：

英国工程与自然科学研究理事会;

关键词：

analytical methods; diffusion; diffusion-ordered spectroscopy; molecular weight; NMR spectroscopy; COMBINATORIAL CHEMISTRY; SPECTROSCOPY;

D O I：

10.1002/anie.201207403

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Appealingly simple: A new method is described that allows the diffusion coefficient of a small molecule to be estimated given only the molecular weight and the viscosity of the solvent used. This method makes possible the quantitative interpretation of the diffusion domain of diffusion-ordered NMR spectra (see picture). © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3199 / 3202

页数：4

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