Epstein-Barr virus latent membrane protein-1 (LMP-1) expression in oral squamous cell carcinoma

被引：37
作者：
Gonzalez-Moles, MA
Gutierrez, J
Rodriguez, MJ
Ruiz-Avila, I
Rodriguez-Archilla, A
机构：
[1] Univ Granada, Fac Odontol, Dept Oral Med, Sch Dent, E-18071 Granada, Spain
[2] Univ Granada, Dept Microbiol, Sch Med, E-18071 Granada, Spain
[3] Gen Hosp Jaen, Dept Pathol, Jaen, Spain
来源：
LARYNGOSCOPE | 2002年 / 112卷 / 03期
关键词：
Epstein-Barr virus; latent membrane protein-1; oral squamous cell carcinoma;
D O I：
10.1097/00005537-200203000-00014
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objectives: Epstein-Barr virus (EBV) is frequently associated with malignant cell transformation through the action of the oncoprotein latent membrane protein-1 (LMP-1). The present study aimed to determine the presence of EBV in oral squamous cell carcinomas (OSCCs) and the expression of LMP-1 in neoplastic cells of EBV-positive OSCCs. Study Design/Methods: In a retrospective study of 78 OSCCs, we investigated the presence of the DNA of EBV by polymerase chain reaction, the expression of the oncoprotein LMP-1 by immunohistochemistry, and the presence of EBV-encoded RNA (EBER) by in situ hybridization. Results: EBV DNA was detected in 19.2% of the cases. Expression of LMP-1 in neoplastic cells was found in 85.7% of the EBV-positive OSCCs. EBV presence was significantly more frequent (P <.05) in OSCCs localized on the lateral tongue. EBV-positive OSCCs more frequently presented (P <.05) greater nuclear atypia. Conclusion: EBV can appear in latent form in OSCC and express its main oncoprotein, LMP-1.
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收藏
页码：482 / 487
页数：6
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