Insulin-like Growth Factor 2 and Insulin-like Growth Factor 2 Receptor Gene Polymorphisms in Idiopathic Male Infertility

OBJECTIVE: To test the association between insulin-like growth factor 2 (IGF2) ApaI and IGF2 receptor (IGF2R) Gly1619Arg gene polymorphisms and idiopathic male infertility. STUDY DESIGN: Polymerase chain reaction and restriction fragment length polymorphism methods were performed to detect the IGF2 ApaI and IGF2R Gly1619Arg genotypes in 98 Croatian men with idiopathic infertility and 113 fertile men. RESULTS: There were no significant differences between patients and controls according to genotype (chi(2)(IGF)=3.46, p=0.177; chi(2)(IGF2R)=1.12, p=0.571, respectively) and allele frequencies (chi(2)(IGF)=3.23, P=0.072; chi(2)(IGF2R)=0.99, p=0.319, respectively). Odds ratios for recessive, dominant and codominant models and association testing with each genotype combination revealed no difference between infertile men and controls. CONCLUSION: In this study we have shown that IGF2 ApaI and IGF2R Gly1619Arg gene polymorphisms are not associated with male infertility. (J Reprod Med 2013;58:132-136)