Binding pattern and toxicological effects of lectins from genus Canavalia on bovine sperm

被引：6
|
作者：
Kaefer, Cristian [1 ]
Komninou, Eliza R. [1 ]
Campos, Vinicius F. [1 ]
de Leon, Priscila M. [1 ]
Arruda, Francisco Vassiliepe S. [2 ]
Nascimento, Kyria S. [2 ]
Teixeira, Edson H. [3 ]
Stefanello, Francielli M. [4 ]
Barschak, Alethea G. [4 ]
Deschamps, Joao Carlos [1 ]
Seixas, Fabiana K. [1 ]
Cavada, Benildo S. [2 ]
Collares, Tiago [4 ]
机构：
[1] Univ Fed Pelotas, Ctr Desenvolvimento Tecnol, Programa Posgrad Biotecnol, Lab Embriol Mol & Transgenese, Pelotas, RS, Brazil
[2] Univ Fed Ceara, Dept Bioquim & Biol Mol, Lab Mol Biologicamente Ativas BioMol, Fortaleza, Ceara, Brazil
[3] Univ Fed Ceara, Dept Patol & Med Legal, Fortaleza, Ceara, Brazil
[4] Univ Fed Pelotas, Ctr Ciencias Quim Farmaceut Alimentos, Programa Posgrad Bioquim & Bioprospeccao, Pelotas, RS, Brazil
来源：
REPRODUCTIVE TOXICOLOGY | 2013年 / 38卷
关键词：
ConA; ConBol; ConBr; Sperm; Oxidative stress; Lipid peroxidation; CONCANAVALIN-A; LIPID-PEROXIDATION; ACROSOME REACTION; HUMAN-SPERMATOZOA; OXYGEN; CAPACITATION; BRASILIENSIS; PHOSPHORYLATION; TRANSMISSION; AGGLUTININ;
D O I：
10.1016/j.reprotox.2013.03.003
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The aim of this study was to determine the binding patterns of Canavalia ensiformis (ConA), Canavalia boliviana (ConBol) and Canavalia brasiliensis (ConBr) lectins to bovine sperm and their effects on sperm motility, viability, lipid peroxidation, reactive oxygen species production and fertilization ability. ConA bound to whole spermatozoa, with the exception of the equatorial segment, ConBol did not interact with the acrosome region and ConBr exhibited a fragmented binding pattern. The three lectins decreased sperm motility but did not affect cell viability or lipid peroxidation. Nevertheless, ROS production was increased in comparison to controls and a reduction in the cleavage and blastocyst ratio was induced in comparison to controls. In conclusion, this study determined that structurally similar lectins interact differently with bovine sperm and affect sperm motility, viability, lipid peroxidation, ROS production and fertilization ability in various ways. (c) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：72 / 80
页数：9
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