Bone marrow mesenchymal stem cells in hepatocellular carcinoma

被引：4
作者：
Gong, Peng [1 ]
Wang, Yingxin [1 ]
Zhang, Jing [1 ]
Wang, Zhongyu [1 ]
机构：
[1] Dalian Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Dalian 116011, Peoples R China
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2013年 / 18卷
基金：
中国国家自然科学基金;
关键词：
Bone marrow mesenchymal stem cells; hepatocellular carcinoma; vascular endothelial cell growth factor; Review; TUMOR-ASSOCIATED FIBROBLASTS; EXTRACELLULAR-MATRIX; STROMAL CELLS; IN-VITRO; GENE-EXPRESSION; HEPATOCYTE DIFFERENTIATION; RAT HEPATOCYTES; GROWTH; CANCER; PROLIFERATION;
D O I：
10.2741/4145
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bone marrow mesenchymal stem cells (BMSCs) are non-hematopoietic multipotent stem cells capable of differentiating into mature cells. Studies in animal models have indicated that hepatocellular carcinoma (HCC) may originate from genetically mutated BMSCs. Moreover, it has been shown that BMSCs are influenced by and can modulate their micro-environment via secreted cytokines that promote tumor initiation, growth, and homing to tumor sites. Based on these features, BMSCs have been recognized as a putative target of molecular therapies to treat and prevent HCC. In this review we discuss the role of human BMSCs in HCC pathogenesis and their therapeutic potential.
引用
收藏
页码：811 / 819
页数：9
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