Ubiquitous expression of a Drosophila adenomatous polyposis coli homolog and its localization in cortical actin caps

被引：26
|
作者：
Yu, X [1 ]
Bienz, M [1 ]
机构：
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
来源：
MECHANISMS OF DEVELOPMENT | 1999年 / 84卷 / 1-2期
关键词：
adenomatous polyposis coil; cortical actin caps; blastoderm embryo; microtubules; Drosophila;
D O I：
10.1016/S0925-4773(99)00072-6
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We report the expression pattern of a new adenomatous polyposis coli (APC) homolog called E-APC during Drosophila development. E-APC protein is expressed in all embryonic and larval cells we have examined. In the early blastoderm embryo, we see a striking concentration of E-APC in the cortical actin caps. Microtubules are closely associated with these caps. Since human APC has been reported to bind to microtubules, we investigated whether the cortical E-APC co-localizes with tubulin. However, this was not the case, implying that the putative tubulin-binding property of human APC is not well conserved. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：69 / 73
页数：5
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