Ubiquitous expression of a Drosophila adenomatous polyposis coli homolog and its localization in cortical actin caps

被引：26
|
作者：
Yu, X [1 ]
Bienz, M [1 ]
机构：
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
来源：
MECHANISMS OF DEVELOPMENT | 1999年 / 84卷 / 1-2期
关键词：
adenomatous polyposis coil; cortical actin caps; blastoderm embryo; microtubules; Drosophila;
D O I：
10.1016/S0925-4773(99)00072-6
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We report the expression pattern of a new adenomatous polyposis coli (APC) homolog called E-APC during Drosophila development. E-APC protein is expressed in all embryonic and larval cells we have examined. In the early blastoderm embryo, we see a striking concentration of E-APC in the cortical actin caps. Microtubules are closely associated with these caps. Since human APC has been reported to bind to microtubules, we investigated whether the cortical E-APC co-localizes with tubulin. However, this was not the case, implying that the putative tubulin-binding property of human APC is not well conserved. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：69 / 73
页数：5
相关论文
共 50 条
  • [1] A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates a-catenin but its zygotic expression is not essential for the regulation of Armadillo
    Proc Natl Acad Sci USA, 1 (242):
  • [2] Regulated binding of adenomatous polyposis coli protein to actin
    Moseley, James B.
    Bartolini, Francesca
    Okada, Kyoko
    Wen, Ying
    Gundersen, Gregg G.
    Goode, Bruce L.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (17) : 12661 - 12668
  • [3] Starting Actin Filaments Anew - Adenomatous Polyposis Coli Is an Actin Nucleator
    Okada, Kyoko
    Deaconescu, Alexandra M.
    Moseley, James B.
    Dogic, Zvonimir
    Grigorieff, Nikolaus
    Goode, Bruce L.
    BIOPHYSICAL JOURNAL, 2009, 96 (03) : 124A - 124A
  • [4] A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo
    Hayashi, S
    Rubinfeld, B
    Souza, B
    Polakis, P
    Wieschaus, E
    Levine, AJ
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (01) : 242 - 247
  • [5] Neuronal localization of the Adenomatous polyposis coli tumor suppressor protein
    Brakeman, JSF
    Gu, SH
    Wang, XB
    Dolin, G
    Baraban, JM
    NEUROSCIENCE, 1999, 91 (02) : 661 - 672
  • [6] Characterization of Adenomatous Polyposis Coli Protein Dynamics and Localization at the Centrosome
    Lui, Christina
    Mok, Myth T. S.
    Henderson, Beric R.
    CANCERS, 2016, 8 (05):
  • [7] Regulation of caspase expression and apoptosis by adenomatous polyposis coli
    Chen, TA
    Yang, I
    Irby, R
    Shain, KH
    Wang, HG
    Quackenbush, J
    Coppola, D
    Cheng, JQ
    Yeatman, TJ
    CANCER RESEARCH, 2003, 63 (15) : 4368 - 4374
  • [8] Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation
    Lee, Wen-Chih
    Beebe, Katherine
    Sudmeier, Lisa
    Micchelli, Craig A.
    DEVELOPMENT, 2009, 136 (13): : 2255 - 2264
  • [9] Drosophila Homologues of Adenomatous Polyposis Coli (APC) and the Formin Diaphanous Collaborate by a Conserved Mechanism to Stimulate Actin Filament Assembly
    Jaiswal, Richa
    Stepanik, Vince
    Rankova, Aneliya
    Molinar, Olivia
    Goode, Bruce L.
    McCartney, Brooke M.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (19) : 13897 - 13905
  • [10] Adenomatous polyposis coli (APC) gene expression in gastric carcinoma
    Grace, A
    Gallagher, M
    Xin, Y
    Leader, M
    Kay, E
    GASTROENTEROLOGY, 1999, 116 (04) : A414 - A414
12345