[1] Univ Lisbon Portugal, Fac Pharm, Res Inst Med iMed ULisboa, Lisbon, Portugal
[2] Univ Coimbra, Fac Med, Ctr Ophtalmol & Vis Sci, Inst Biomed Res Light & Image IBILI, Coimbra, Portugal
[3] Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Ciencias Vida, Caparica, Portugal
[4] Univ Lisbon Portugal, Fac Pharm, Dept Biochem & Human Biol, Lisbon, Portugal
[5] Univ Dundee, Ninewells Hosp & Med Sch, Div Canc Res, Med Res Inst,Jacqui Wood Canc Ctr, Dundee DD1 9SY, Scotland