Should CYP2D6 be genotyped when treating with tamoxifen?

被引：4

作者：

Del Re, Marzia ^{[1
]}

Rofi, Eleonora ^{[1
]}

Citi, Valentina ^{[1
]}

Fidilio, Leonardo ^{[1
]}

Danesi, Romano ^{[1
]}

机构：

[1] Univ Pisa, Dept Clin & Expt Med, Clin Pharmacol & Pharmacogenet Unit, 55 Via Roma, I-56126 Pisa, Italy

来源：

PHARMACOGENOMICS | 2016年 / 17卷 / 18期

关键词：

CYP2D6; drug-drug interaction; pharmacogenetics; tamoxifen; BREAST-CANCER; POSTMENOPAUSAL WOMEN; PHARMACOGENETICS; METABOLISM; EFFICACY; THERAPY; RISK;

D O I：

10.2217/pgs-2016-0162

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：1967 / 1969

页数：3

共 20 条

[1] EXCESSIVE CYCLING CONVERTS PCR PRODUCTS TO RANDOM-LENGTH HIGHER MOLECULAR-WEIGHT FRAGMENTS [J].

BELL, DA ;

DEMARINI, DM .

NUCLEIC ACIDS RESEARCH, 1991, 19 (18) :5079-5079

[2] Breast Cancer Risk Reduction [J].

Bevers, Therese B. ;

Armstrong, Deborah K. ;

Arun, Banu ;

Carlson, Robert W. ;

Cowan, Kenneth H. ;

Daly, Mary B. ;

Fleming, Irvin ;

Garber, Judy E. ;

Gemignani, Mary ;

Gradishar, William J. ;

Krontiras, Helen ;

Kulkarni, Swati ;

Laronga, Christine ;

Loftus, Loretta ;

MacDonald, Deborah J. ;

Mahoney, Martin C. ;

Merajver, Sofia D. ;

Meszoely, Ingrid ;

Newman, Lisa ;

Pritchard, Elizabeth ;

Seewaldt, Victoria ;

Sellin, Rena V. ;

Shapiro, Charles L. ;

Ward, John H. .

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2010, 8 (10) :1112-1146

[3] Polymorphism in the CYP2D6 tamoxifen-metabolizing gene influences clinical effect but not hot flashes:: Data from the Italian tamoxifen trial [J].

Bonanni, Bernardo ;

Macis, Debora ;

Maisonneuve, Patrick ;

Johansson, Harriet A. ;

Gucciardo, Giacomo ;

Oliviero, Pasquale ;

Travaglini, Roberto ;

Muraca, Maria G. ;

Rotmensz, Nicole ;

Veronesi, Umberto ;

Decensi, Andrea U. .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (22) :3708-3709

[4] Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism:: Implication for optimization of breast cancer treatment [J].

Borges, Silvana ;

Desta, Zeruesenay ;

Li, Lang ;

Skaar, Todd C. ;

Ward, Bryan A. ;

Nguyen, Anne ;

Jin, Yan ;

Storniolo, Anna Maria ;

Nikoloff, D. Michele ;

Wu, Lin ;

Hillman, Grant ;

Hayes, Daniel F. ;

Stearns, Vered ;

Flockhart, David A. .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2006, 80 (01) :61-74

[5] Prevention of fluoropyrimidine toxicity: do we still have to try our patient's luck? [J].

Danesi, R. ;

Del Re, M. ;

Ciccolini, J. ;

Schellens, J. H. M. ;

Schwab, M. ;

van Schaik, R. H. N. ;

van Kuilenburg, A. B. P. .

ANNALS OF ONCOLOGY, 2017, 28 (01) :183-183

[6] CYP2D6 Genotyping and Tamoxifen: An Unfinished Story in the Quest for Personalized Medicine [J].

de Souza, Jonas A. ;

Olopade, Olufunmilayo I. .

SEMINARS IN ONCOLOGY, 2011, 38 (02) :263-273

[7] CYP2D6 genotype in relation to tamoxifen efficacy in a Dutch cohort of the tamoxifen exemestane adjuvant multinational (TEAM) trial [J].

Dezentje, V. O. ;

van Schaik, R. H. N. ;

Vletter-Bogaartz, J. M. ;

van der Straaten, T. ;

Wessels, J. A. M. ;

Kranenbarg, E. M. -K. ;

Berns, E. M. ;

Seynaeve, C. ;

Putter, H. ;

van de Velde, C. J. H. ;

Nortier, J. W. R. ;

Gelderblom, H. ;

Guchelaar, H. -J. .

BREAST CANCER RESEARCH AND TREATMENT, 2013, 140 (02) :363-373

[8] Application of a pharmacokinetic/pharmacogenetic approach to assess the nicotine metabolic profile of smokers in the real-life setting [J].

Fogli, Stefano ;

Saba, Alessandro ;

Del Re, Marzia ;

Pistelli, Francesco ;

Aquilini, Ferruccio ;

Zucchi, Riccardo ;

Palla, Antonio ;

Breschi, Maria Cristina ;

Carrozzi, Laura ;

Danesi, Romano .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2016, 131 :208-213

[9] St. Gallen 2011: Summary of the Consensus Discussion [J].

Gnant, Michael ;

Harbeck, Nadia ;

Thomssen, Christoph .

BREAST CARE, 2011, 6 (02) :136-141

[10] Loss of Heterozygosity at the CYP2D6 Locus in Breast Cancer: Implications for Germline Pharmacogenetic Studies [J].

Goetz, Matthew P. ;

Sun, James X. ;

Suman, Vera J. ;

Silva, Grace O. ;

Perou, Charles M. ;

Nakamura, Yusuke ;

Cox, Nancy J. ;

Stephens, Philip J. ;

Miller, Vincent A. ;

Ross, Jeffrey S. ;

Chen, David ;

Safgren, Stephanie L. ;

Kuffel, Mary J. ;

Ames, Matthew M. ;

Kalari, Krishna R. ;

Gomez, Henry L. ;

Gonzalez-Angulo, Ana M. ;

Burgues, Octavio ;

Brauch, Hiltrud B. ;

Ingle, James N. ;

Ratain, Mark J. ;

Yelensky, Roman .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2015, 107 (02)

← 1 2 →