Distribution of Pilus Islands in Streptococcus agalactiae That Cause Human Infections: Insights into Evolution and Implication for Vaccine Development

被引:44
作者
Martins, E. R. [1 ]
Andreu, A. [2 ]
Melo-Cristino, J. [1 ]
Ramirez, M. [1 ]
机构
[1] Univ Lisbon, Inst Microbiol, Inst Med Mol, Fac Med, P-1699 Lisbon, Portugal
[2] Univ Autonoma Barcelona, Microbiol Serv, Hosp Vall dHebron, E-08193 Barcelona, Spain
关键词
GROUP-B STREPTOCOCCI; TYPING METHODS; NONPREGNANT ADULTS; IDENTIFICATION; PORTUGAL; DISEASE; GENOME; WOMEN;
D O I
10.1128/CVI.00529-12
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
At least one pilus island, PI-1 (70%), PI-2a (79%), or PI-2b (21%), was found among 898 Streptococcus agalactiae (group B streptococcus [GBS]) isolates recovered from humans, supporting the use of pilus proteins in vaccines. The stability and dominance of PI-1 and PI-2a in multiple serotypes and founder multilocus sequence types disseminated worldwide suggest it could be the PI combination present in ancestral GBS human pathogens.
引用
收藏
页码:313 / 316
页数:4
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