DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters

被引：74
作者：
Ichikawa, Natsuko [1 ]
Sasagawa, Machi [1 ]
Yamamoto, Mika [1 ]
Komaki, Hisayuki [1 ]
Yoshida, Yumi [1 ]
Yamazaki, Shuji [1 ]
Fujita, Nobuyuki [1 ]
机构：
[1] Natl Inst Technol & Evaluat NBRC, Biol Resource Ctr, Shibuya Ku, Tokyo 1510006, Japan
来源：
NUCLEIC ACIDS RESEARCH | 2013年 / 41卷 / D1期
关键词：
DRAFT GENOME SEQUENCE; POLYKETIDE SYNTHASE; IDENTIFICATION; ANTIBIOTICS; ANNOTATION; PROTEIN;
D O I：
10.1093/nar/gks1177
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This article introduces DoBISCUIT (Database of BIoSynthesis clusters CUrated and InTegrated, http://www.bio.nite.go.jp/pks/), a literature-based, manually curated database of gene clusters for secondary metabolite biosynthesis. Bacterial secondary metabolites often show pharmacologically important activities and can serve as lead compounds and/or candidates for drug development. Biosynthesis of each secondary metabolite is catalyzed by a number of enzymes, usually encoded by a gene cluster. Although many scientific papers describe such gene clusters, the gene information is not always described in a comprehensive manner and the related information is rarely integrated. DoBISCUIT integrates the latest literature information and provides standardized gene/module/domain descriptions related to the gene clusters.
引用
收藏
页码：D408 / D414
页数：7
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