Synthetic approach to flavanones and flavones via ligand-free palladium(II)-catalyzed conjugate addition of arylboronic acids to chromones

被引：50

作者：

Kim, Donghee ^{[1
]}

Ham, Kyungrok ^{[1
]}

Hong, Sungwoo ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem, Taejon 305701, South Korea

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 36期

基金：

新加坡国家研究基金会;

关键词：

ASYMMETRIC 1,4-ADDITION; ALPHA; BETA-UNSATURATED KETONES; ACETYLENES; ANNULATION; ALDEHYDES; CHALCONE; CATALYST; IODIDES;

D O I：

10.1039/c2ob26061a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The remarkable catalytic effects of Fe(OTf)(3) in the context of the Pd(II)-catalyzed conjugate addition of arylboronic acids to chromones were observed to yield a variety of flavanones under mild conditions. The addition of catalytic amounts of DDQ and KNO2 to the reactions exclusively yielded flavone analogs. The reaction scope for the transformation was fairly broad, affording good yields of a wide range of flavanones and flavones, which are privileged structures in many biologically active compounds.

引用

页码：7305 / 7312

页数：8

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