Induction of RANTES and CCR5 through NF-κB activation via MAPK pathway in aged rat gingival tissues

被引：22

作者：

Kim, HK

Park, HR

Sul, KH

Chung, H

Chung, J ^{[1
]}

机构：

[1] Pusan Natl Univ, Sch Dent, Dept Microbiol, Pusan 602739, South Korea

[2] Pusan Natl Univ, Res Inst Genet Engn, Pusan 609735, South Korea

[3] Pusan Natl Univ, Sch Dent, Dept Oral Pathol, Pusan 602739, South Korea

[4] Pusan Natl Univ, Res Inst Oral Biotechnol, Pusan 602739, South Korea

[5] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea

来源：

BIOTECHNOLOGY LETTERS | 2006年 / 28卷 / 01期

关键词：

aging; chemokine receptors; chemokines; gingival tissue; MAPK; NF-kappa B;

D O I：

10.1007/s10529-005-4681-6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chemokine and chemokine receptor expression in gingival tissues plays a central role in periodontal disease during aging. In the present study, we explored the modulation of chemokines and chemokine receptors expression in aging rat gingival tissues. In the 24-month-old (Old) rat gingival tissues, RANTES and CCR5 mRNA and protein levels were 2-4 fold increased over those of the 6-month-old (Young) rats. The Old rats had considerable enhancement of all three of the studied MAPK activities: extracellular signal regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAPK. These results suggest that age-related increases in RANTES and CCR5 expression are associated with increased I kappa B alpha, nuclear NF-kappa B, and MAPK activity in gingival tissues.

引用

页码：17 / 23

页数：7

共 9 条

[1] Characterization of cellular infiltrate, detection of chemokine receptor CCR5 and interleukin-8 and RANTES chemokines in adult periodontitis [J].