N-methyl-bacillithiol, a Novel Thiol from Anaerobic Bacteria

被引：4

作者：

Newton, Gerald L. ^{[1
]}

Rawat, Mamta ^{[2
]}

机构：

[1] Univ Calif San Diego, Div Biol Sci, San Diego, CA 92103 USA

[2] Calif State Univ Fresno, Dept Biol, Fresno, CA 93740 USA

来源：

MBIO | 2019年 / 10卷 / 01期

关键词：

Chlorobium; N-methyl-bacillithiol; anaerobes; bacillithiol; glutathione; thiols; GLUTATHIONE AMIDE; IDENTIFICATION; DETOXIFICATION; TRANSFERASE; METABOLISM; RESISTANCE; MYCOTHIOL;

D O I：

10.1128/mBio.02634-18

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

J. Hiras, S. V. Sharma, V. Raman, R. A. J. Tinson, et al. (mBio 9: e01603-18, 2018, https://doi.org/10.1128/mBio.01603-18) report on the identification of a novel thiol, N-methyl-bacillithiol (N-Me-BSH), in the green sulfur bacterium Chlorobium tepidum. In N-methyl-bacillithiol, the amine of the cysteine is methylated by a novel S-adenosylmethioneine transferase designated N-methyl-bacillithiol synthase A (NmbA). The Hiras et al. study is significant because it is the first report of the presence of N-Me-BSH in anaerobic bacteria.

引用

页数：5

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