Bio-nanotechnology and photodynamic therapy - State of the art review

被引：159

作者：

Allison, R. R. ^{[1
]}

Mota, H. C. ^{[1
]}

Bagnato, V. S. ^{[2
]}

Sibata, C. H. ^{[1
]}

机构：

[1] Brody Sch Med ECU, Greenville, NC 28758 USA

[2] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13566590 Sao Carlos, SP, Brazil

来源：

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2008年 / 5卷 / 01期

关键词：

photodynamic therapy; photodiagnosis; nanotechnology; review; nanoparticles;

D O I：

10.1016/j.pdpdt.2008.02.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Photodynamic therapy (PDT) and bio-nanotechnology (NT) show striking similarities in clinical design and mechanistics. The PDT paradigm of photosensitizer application, tight activation and singlet oxygen generation does in fact occur on the nanoscale level. as does the resultant outcomes. NT has the ability to explain as well as modify each of the critical steps of PDT particularly photosensitizer design and delivery, light source miniaturization and optimization, location and intensity of the photodynamic reaction as welt as offering a far greater insight into dosimetry and mechanisms of action. This review wilt explore the current and potential future interactions and modifications NT may have on PDT. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：19 / 28

页数：10

共 77 条

[1] Real-time detection of virus particles and viral protein expression with two-color nanoparticle probes [J].