Differential Effect of Insulin Like Growth Factor-I on Constriction of Human Uterine and Placental Arteries

被引:9
作者
Corcoran, Jemma J. [1 ]
Charnock, Jayne C. [1 ]
Martin, Julie [2 ]
Taggart, Michael J. [2 ]
Westwood, Melissa [1 ]
机构
[1] Univ Manchester, Maternal & Fetal Hlth Res Ctr, St Marys Hosp, Acad Hlth Sci Ctr, Manchester M13 9WL, Lancs, England
[2] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
基金
英国医学研究理事会;
关键词
CHORIONIC PLATE ARTERIES; FACTOR-BINDING PROTEIN-1; INTRAUTERINE GROWTH; IGF-I; POSTNATAL-GROWTH; EARLY-PREGNANCY; FETAL-GROWTH; PREECLAMPSIA; THROMBOXANE; RELAXATION;
D O I
10.1210/jc.2012-1679
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Context: Discrete regulation of the uterine and placental vasculatures is an important feature of uteroplacental perfusion and pregnancy success because appropriate maternal/fetal exchange of nutrients and gases is crucial for normal fetal growth. Placental vasculature lacks autonomic innervation so tone is controlled by locally derived vasoactive factors. IGF-I, which is produced by the placenta, is critical for normal fetal growth and studies of animal vascular systems have shown that IGF-I regulates vasomotor tone. Objective: The objective of the study was to determine whether IGF-I directly alters human placental and myometrial arterial tone in vitro. Participants: Women with uncomplicated pregnancy delivering a singleton infant at term participated in the study. Setting: The study was conducted at university hospital laboratories. Main Outcome Measure(s): Comparison of arterial tension measured before and after exposure to IGF-I. Design: Placental and myometrial arteries were mounted on a wire myograph, exposed to the constrictor U46619 (10(-10) to 10(-5) M), returned to baseline tension, and then incubated with IGF-I (0-500 ng/ml) for various time points before performing a second dose-response curve to U46619. IGF-I receptor protein expression was assessed. Results: IGF-I did not acutely alter the response of placental arteries to U46619. Exposure of myometrial arteries to IGF-I caused a rightward shift of U46619 dose-response curves (P < 0.05); EC50 data were significantly increased at 30 (15.5 +/- 2.8 vs. 133 +/- 44 nM, before and after IGF treatment, respectively) and 60 min (10.9 +/- 1.9 vs. 146 +/- 47 nM). Placental and myometrial arteries had a similar IGF-I receptor expression profile. Conclusions: IGF-I acutely modulates the vasomotor tone of human myometrial, but not placental, arteries, suggesting that IGF-I regulates the delivery of maternal blood to the placenta. (J Clin Endocrinol Metab 97: E2098-E2104, 2012)
引用
收藏
页码:E2098 / E2104
页数:7
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