Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide

被引：45

作者：

Thompson, Pamela ^{[1
,2
]}

Lakshminarayanan, Vani ^{[3
,4
]}

Supekar, Nitin T. ^{[1
,2
]}

Bradley, Judy M. ^{[4
,5
]}

Cohen, Peter A. ^{[4
,5
]}

Wolfert, Margreet A. ^{[1
]}

Gendler, Sandra J. ^{[3
,4
]}

Boons, Geert-Jan ^{[1
,2
]}

机构：

[1] Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA

[2] Univ Georgia, Dept Chem, Athens, GA 30602 USA

[3] Mayo Clin, Coll Med, Dept Biochem & Mol Biol & Immunol, Scottsdale, AZ 85259 USA

[4] Mayo Clin, Ctr Comprehens Canc, Scottsdale, AZ 85259 USA

[5] Mayo Clin, Coll Med, Dept Hematol & Oncol, Scottsdale, AZ 85259 USA

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 50期

基金：

美国国家卫生研究院;

关键词：

ABERRANTLY GLYCOSYLATED MUC1; SOLID-PHASE SYNTHESIS; TOLL-LIKE RECEPTOR-2; T-CELL EPITOPE; BREAST-CANCER; TUMOR-CELLS; CARBOHYDRATE ANTIGENS; ANTITUMOR VACCINES; ANTICANCER VACCINE; ALPHA-SIALOSIDES;

D O I：

10.1039/c5cc02199e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A strategy for the linear synthesis of a sialylated glycolipopeptide cancer vaccine candidate has been developed using a strategically designed sialyl-Tn building block and microwave-assisted solid-phase peptide synthesis. The glycolipopeptide elicited potent humoral and cellular immune responses. T-cells primed by such a vaccine candidate could be restimulated by tumor-associated MUC1.

引用

页码：10214 / 10217

页数：4

共 56 条

[1] Immune and Anticancer Responses Elicited by Fully Synthetic Aberrantly Glycosylated MUC1 Tripartite Vaccines Modified by a TLR2 or TLR9 Agonist [J].

Abdel-Aal, Abu-Baker M. ;

Lakshminarayanan, Vani ;

Thompson, Pamela ;

Supekar, Nitin ;

Bradley, Judy M. ;

Wolfert, Margreet A. ;

Cohen, Peter A. ;

Gendler, Sandra J. ;

Boons, Geert-Jan .

CHEMBIOCHEM, 2014, 15 (10) :1508-1513

[2] MUC1 immunotherapy [J].

Beatson, Richard E. ;

Taylor-Papadimitriou, Joyce ;

Burchell, Joy M. .

IMMUNOTHERAPY, 2010, 2 (03) :305-327

[3] Autoantibodies to aberrantly glycosylated MUC1 in early stage breast cancer are associated with a better prognosis [J].

Blixt, Ola ;

Bueti, Deanna ;

Burford, Brian ;

Allen, Diane ;

Julien, Sylvain ;

Hollingsworth, Michael ;

Gammerman, Alex ;

Fentiman, Ian ;

Taylor-Papadimitriou, Joyce ;

Burchell, Joy M. .

BREAST CANCER RESEARCH, 2011, 13 (02)

[4] Towards a fully synthetic carbohydrate-based anticancer vaccine: Synthesis and immunological evaluation of a lipidated glycopeptide containing the tumor-associated Tn antigen [J].

Buskas, T ;

Ingale, S ;

Boons, GJ .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (37) :5985-5988

[5] The immunogenicity of the tumor-associated antigen Lewisy may be suppressed by a bifunctional cross-linker required for coupling to a carrier protein [J].

Buskas, T ;

Li, YH ;

Boons, GJ .

CHEMISTRY-A EUROPEAN JOURNAL, 2004, 10 (14) :3517-3524

[6] Synthetic Multivalent Glycopeptide-Lipopeptide Antitumor Vaccines: Impact of the Cluster Effect on the Killing of Tumor Cells [J].

Cai, Hui ;

Sun, Zhan-Yi ;

Chen, Mei-Sha ;

Zhao, Yu-Fen ;

Kunz, Horst ;

Li, Yan-Mei .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 53 (06) :1699-1703

[7] Fully Synthetic Self-Adjuvanting Thioether-Conjugated GlycopeptideLipopeptide Antitumor Vaccines for the Induction of Complement-Dependent Cytotoxicity against Tumor Cells [J].

Cai, Hui ;

Sun, Zhan-Yi ;

Huang, Zhi-Hua ;

Shi, Lei ;

Zhao, Yu-Fen ;

Kunz, Horst ;

Li, Yan-Mei .

CHEMISTRY-A EUROPEAN JOURNAL, 2013, 19 (06) :1962-1970

[8] Towards a Fully Synthetic MUC1-Based Anticancer Vaccine: Efficient Conjugation of Glycopeptides with Mono-, Di-, and Tetravalent Lipopeptides Using Click Chemistry [J].

Cai, Hui ;

Huang, Zhi-Hua ;

Shi, Lei ;

Zhao, Yu-Fen ;

Kunz, Horst ;

Li, Yan-Mei .

CHEMISTRY-A EUROPEAN JOURNAL, 2011, 17 (23) :6396-6406

[9] Sialyl Tn-expressing bladder cancer cells induce a tolerogenic phenotype in innate and adaptive immune cells [J].

Carrascal, Mylene A. ;

Severino, Paulo F. ;

Guadalupe Cabral, M. ;

Silva, Mariana ;

Ferreira, Jose Alexandre ;

Calais, Fernando ;

Quinto, Herminia ;

Pen, Claudia ;

Ligeiro, Dario ;

Santos, Lucio Lara ;

Dall'Olio, Fabio ;

Videira, Paula A. .

MOLECULAR ONCOLOGY, 2014, 8 (03) :753-765

[10] Tumour-associated carbohydrate antigens in breast cancer [J].

Cazet, Aurelie ;

Julien, Sylvain ;

Bobowski, Marie ;

Burchell, Joy ;

Delannoy, Philippe .

BREAST CANCER RESEARCH, 2010, 12 (03)

← 1 2 3 4 5 6 →