Innate vs. Adaptive: PD-L1-mediated immune resistance by melanoma

被引：28

作者：

Berry, Sneha ^{[1
,2
]}

Taube, Janis M. ^{[1
,2
,3
,4
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[2] Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA

[3] Johns Hopkins Univ, Sch Med, Dept Dermatol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

来源：

ONCOIMMUNOLOGY | 2015年 / 4卷 / 10期

关键词：

adaptive immune resistance; BRAF; melanoma; PD-L1; TIL; PD-L1; EXPRESSION;

D O I：

10.1080/2162402X.2015.1029704

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oncogenic driver mutations in several tumor types promote constitutive PD-L1 expression, a crucial ligand in PD-1-mediated tumor immune escape. Our studies in melanoma suggest a different mechanism-one of "adaptive immune resistance" in which PD-L1 expression is primarily driven by cytokine induction and is independent of BRAF mutational status.

引用

页数：3

共 10 条

[1] Effects of MAPK and PI3K Pathways on PD-L1 Expression in Melanoma [J].

Atefi, Mohammad ;

Avramis, Earl ;

Lassen, Amanda ;

Wong, Deborah J. L. ;

Robert, Lidia ;

Foulad, David ;

Cerniglia, Michael ;

Titz, Bjoern ;

Chodon, Thinle ;

Graeber, Thomas G. ;

Comin-Anduix, Begonya ;

Ribas, Antoni .

CLINICAL CANCER RESEARCH, 2014, 20 (13) :3446-3457

[2] Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma [J].

Green, Michael R. ;

Monti, Stefano ;

Rodig, Scott J. ;

Juszczynski, Przemyslaw ;

Currie, Treeve ;

O'Donnell, Evan ;

Chapuy, Bjoern ;

Takeyama, Kunihiko ;

Neuberg, Donna ;

Golub, Todd R. ;

Kutok, Jeffery L. ;

Shipp, Margaret A. .

BLOOD, 2010, 116 (17) :3268-3277

[3] PD-L1 Expression in the Merkel Cell Carcinoma Microenvironment: Association with Inflammation, Merkel Cell Polyomavirus, and Overall Survival [J].

Lipson, Evan J. ;

Vincent, Jeremy G. ;

Loyo, Myriam ;

Kagohara, Luciane T. ;

Luber, Brandon S. ;

Wang, Hao ;

Xu, Haiying ;

Nayar, Suresh K. ;

Wang, Timothy S. ;

Sidransky, David ;

Anders, Robert A. ;

Topalian, Suzanne L. ;

Taube, Janis M. .

CANCER IMMUNOLOGY RESEARCH, 2013, 1 (01) :54-63

[4] Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma [J].

Parsa, Andrew T. ;

Waldron, James S. ;

Panner, Amith ;

Crane, Courtney A. ;

Parney, Ian F. ;

Barry, Jeffrey J. ;

Cachola, Kristine E. ;

Murray, Joseph C. ;

Tihan, Tarik ;

Jensen, Michael C. ;

Mischel, Paul S. ;

Stokoe, David ;

Pieper, Russell O. .

NATURE MEDICINE, 2007, 13 (01) :84-88

[5] PD-L1 Expression in Melanocytic Lesions Does Not Correlate with the BRAF V600E Mutation [J].

Rodic, Nemanja ;

Anders, Robert A. ;

Eshleman, James R. ;

Lin, Ming-Tseh ;

Xu, Haiying ;

Kim, Jung H. ;

Beierl, Katie ;

Chen, Shuming ;

Luber, Brandon S. ;

Wang, Hao ;

Topalian, Suzanne L. ;

Pardoll, Drew M. ;

Taube, Janis M. .

CANCER IMMUNOLOGY RESEARCH, 2015, 3 (02) :110-115

[6] Association of PD-1, PD-1 Ligands, and Other Features of the Tumor Immune Microenvironment with Response to Anti-PD-1 Therapy [J].

Taube, Janis M. ;

Klein, Alison ;

Brahmer, Julie R. ;

Xu, Haiying ;

Pan, Xiaoyu ;

Kim, Jung H. ;

Chen, Lieping ;

Pardoll, Drew M. ;

Topalian, Suzanne L. ;

Anders, Robert A. .

CLINICAL CANCER RESEARCH, 2014, 20 (19) :5064-5074

[7] Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape [J].

Taube, Janis M. ;

Anders, Robert A. ;

Young, Geoffrey D. ;

Xu, Haiying ;

Sharma, Rajni ;

McMiller, Tracee L. ;

Chen, Shuming ;

Klein, Alison P. ;

Pardoll, Drew M. ;

Topalian, Suzanne L. ;

Chen, Lieping .

SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (127)

[8] PD-1 blockade induces responses by inhibiting adaptive immune resistance [J].

Tumeh, Paul C. ;

Harview, Christina L. ;

Yearley, Jennifer H. ;

Shintaku, I. Peter ;

Taylor, Emma J. M. ;

Robert, Lidia ;

Chmielowski, Bartosz ;

Spasic, Marko ;

Henry, Gina ;

Ciobanu, Voicu ;

West, Alisha N. ;

Carmona, Manuel ;

Kivork, Christine ;

Seja, Elizabeth ;

Cherry, Grace ;

Gutierrez, Antonio J. ;

Grogan, Tristan R. ;

Mateus, Christine ;

Tomasic, Gorana ;

Glaspy, John A. ;

Emerson, Ryan O. ;

Robins, Harlan ;

Pierce, Robert H. ;

Elashoff, David A. ;

Robert, Caroline ;

Ribas, Antoni .

NATURE, 2014, 515 (7528) :568-+

[9] Selective BRAF Inhibitors Induce Marked T-cell Infiltration into Human Metastatic Melanoma [J].

Wilmott, James S. ;

Long, Georgina V. ;

Howle, Julie R. ;

Haydu, Lauren E. ;

Sharma, Raghwa N. ;

Thompson, John F. ;

Kefford, Richard F. ;

Hersey, Peter ;

Scolyer, Richard A. .

CLINICAL CANCER RESEARCH, 2012, 18 (05) :1386-1394

[10]

Young GD, 2013, CANCER RES, V73, P6

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