Longitudinal reproducibility of automatically segmented hippocampal subfields: A multisite European 3T study on healthy elderly

被引：33

作者：

Marizzoni, Moira ^{[1
]}

Antelmi, Luigi ^{[2
,3
,4
]}

Bosch, Beatriz ^{[5
,6
]}

Bartres-Faz, David ^{[5
,6
]}

Mueller, Bernhard W. ^{[7
]}

Wiltfang, Jens ^{[8
]}

Fiedler, Ute ^{[7
]}

Roccatagliata, Luca ^{[9
,10
,11
]}

Picco, Agnese ^{[12
]}

Nobili, Flavio ^{[12
]}

Blin, Olivier ^{[13
]}

Bombois, Stephanie ^{[14
]}

Lopes, Renaud ^{[15
]}

Sein, Julien ^{[16
]}

Ranjeva, Jean-Philippe ^{[16
]}

Didic, Mira ^{[17
,18
]}

Gros-Dagnac, Helene ^{[19
,20
]}

Payoux, Pierre ^{[19
,20
]}

Zoccatelli, Giada ^{[21
]}

Alessandrini, Franco ^{[21
]}

Beltramello, Alberto ^{[21
]}

Bargallo, Nuria ^{[22
,23
]}

Ferretti, Antonio ^{[24
,25
]}

Caulo, Massimo ^{[24
,25
]}

Aiello, Marco ^{[26
]}

Cavaliere, Carlo ^{[26
]}

Soricelli, Andrea ^{[26
,27
]}

Salvadori, Nicola ^{[28
]}

Parnetti, Lucilla ^{[28
]}

Tarducci, Roberto ^{[29
]}

Floridi, Piero ^{[30
]}

Tsolaki, Magda ^{[31
]}

Constantinidis, Manos ^{[32
]}

Drevelegas, Antonios ^{[32
,33
]}

Rossini, Paolo Maria ^{[34
,35
]}

Marra, Camillo ^{[36
]}

Hoffmann, Karl-Titus ^{[37
]}

Hensch, Tilman ^{[38
]}

Schoenknecht, Peter ^{[38
]}

Kuijer, Joost P. ^{[39
]}

Visser, Pieter Jelle ^{[40
]}

Barkhof, Frederik ^{[41
]}

Bordet, Regis ^{[42
]}

Frisoni, Giovanni B. ^{[1
,2
,3
,4
]}

Jovicich, Jorge ^{[43
]}

机构：

[1] IRCCS, San Giovanni Dio FBF, LENITEM Lab Epidemiol Neuroimaging & Telemed, Brescia, Italy

[2] Univ Hosp Geneva, Memory Clin, Geneva, Switzerland

[3] Univ Hosp Geneva, LANVIE, Lab Neuroimaging Aging, Geneva, Switzerland

[4] Univ Geneva, Geneva, Switzerland

[5] Univ Barcelona, Dept Psychiat & Clin Psychobiol, Barcelona, Spain

[6] IDIBAPS, Barcelona, Spain

[7] Univ Duisburg Essen, LVR Clin Psychiat & Psychotherapy, Inst & Clin, Essen, Germany

[8] Univ Gottingen, Univ Med Ctr UMG, Dept Psychiat & Psychotherapy, D-37073 Gottingen, Germany

[9] IRCSS San Martino Univ Hosp, Dept Neuroradiol, Genoa, Italy

[10] IST, Genoa, Italy

[11] Univ Genoa, Dept Hlth Sci, Genoa, Italy

[12] Univ Genoa, Dept Neurosci Ophthalmol Genet & Mother Child Hlt, Genoa, Italy

[13] Aix Marseille Univ, CNRS, Assistance Publ Hop Marseille, Pharmacol,UMR 7289, Marseille, France

[14] Univ Lille, Dept Neurol, INSERM, U1171, Lille, France

[15] Univ Lille, Dept Neuroradiol, INSERM, U1171, Lille, France

[16] Aix Marseille Univ, CRMBM CEMEREM, UMR 7339, CNRS, Marseille, France

[17] CHU Timone, APHM, Serv Neurol & Neuropsychol, Marseille, France

[18] Aix Marseille Univ, INSERM, INS UMR S 1106, F-13005 Marseille, France

[19] INSERM, Imagerie Cerebrale & Handicaps Neurol, F-31024 Toulouse, France

[20] Univ Toulouse 3, UMR 825, Imagerie Cerebrale & Handicaps Neurol, F-31024 Toulouse, France

[21] Univ Hosp, Serv Neuroradiol, Verona, Italy

[22] Hosp Clin Barcelona, IDIBAPS, Dept Neuroradiol, Barcelona, Spain

[23] Hosp Clin Barcelona, IDIBAPS, Magnet Resonace Image Core Facil, Barcelona, Spain

[24] Univ G DAnnunzio, Dept Neurosci Imaging & Clin Sci, Chieti, Italy

[25] Univ G DAnnunzio, Inst Adv Biomed Technol ITAB, Chieti, Italy

[26] IRCCS, SDN, Naples, Italy

[27] Univ Naples Parthenope, Naples, Italy

[28] Univ Perugia, Ctr Memory Disturbances, Neurol Sect, I-06100 Perugia, Italy

[29] Perugia Gen Hosp, Med Phys Unit, Perugia, Italy

[30] Perugia Gen Hosp, Neuroradiol Unit, Perugia, Italy

[31] Aristotle Univ Thessaloniki, Dept Neurol 3, GR-54006 Thessaloniki, Greece

[32] Interbalkan Med Ctr Thessaloniki, Thessaloniki, Greece

[33] Aristotle Univ Thessaloniki, Dept Radiol, GR-54006 Thessaloniki, Greece

[34] Catholic Univ, Dept Geriatr Neurosci & Orthopaed, Policlin Gemelli, Rome, Italy

[35] IRCCS, S Raffaele Pisana, Brescia, Italy

[36] Catholic Univ, Ctr Neuropsychol Res, Rome, Italy

[37] Univ Hosp, Dept Neuroradiol, Leipzig, Germany

[38] Univ Hosp, Dept Psychiat & Psychotherapy, Leipzig, Germany

[39] Vrije Univ Amsterdam, Dept Phys & Med Technol, Med Ctr, Amsterdam, Netherlands

[40] Univ Maastricht, Alzheimer Ctr Limburg, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

[41] Vrije Univ Amsterdam, Med Ctr, Radiol & Image Anal Ctr IAC, Amsterdam, Netherlands

[42] Univ Lille, Dept Pharmacol, INSERM, U1171, Lille, France

[43] Univ Trento, Ctr Mind Brain Sci CIMEC, Rovereto, Italy

来源：

HUMAN BRAIN MAPPING | 2015年 / 36卷 / 09期

基金：

欧盟第七框架计划;

关键词：

hippocampus; Freesurfer; within session T1 averaging; test-retest reproducibility; MRI; ATROPHY; SCHIZOPHRENIA; RELIABILITY; VOLUMES; DISEASE; AGE;

D O I：

10.1002/hbm.22859

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recently, there has been an increased interest in the use of automatically segmented subfields of the human hippocampal formation derived from magnetic resonance imaging (MRI). However, little is known about the test-retest reproducibility of such measures, particularly in the context of multisite studies. Here, we report the reproducibility of automated Freesurfer hippocampal subfields segmentations in 65 healthy elderly enrolled in a consortium of 13 3T MRI sites (five subjects per site). Participants were scanned in two sessions (test and retest) at least one week apart. Each session included two anatomical 3D T1 MRI acquisitions harmonized in the consortium. We evaluated the test-retest reproducibility of subfields segmentation (i) to assess the effects of averaging two within-session T1 images and (ii) to compare subfields with whole hippocampus volume and spatial reliability. We found that within-session averaging of two T1 images significantly improved the reproducibility of all hippocampal subfields but not that of the whole hippocampus. Volumetric and spatial reproducibility across MRI sites were very good for the whole hippocampus, CA2-3, CA4-dentate gyrus (DG), subiculum (reproducibility error approximate to 2% and DICE>0.90), good for CA1 and presubiculum (reproducibility error approximate to 5% and DICE approximate to 0.90), and poorer for fimbria and hippocampal fissure (reproducibility error approximate to 15% and DICE<0.80). Spearman's correlations confirmed that test-retest reproducibility improved with volume size. Despite considerable differences of MRI scanner configurations, we found consistent hippocampal subfields volumes estimation. CA2-3, CA4-DG, and sub-CA1 (subiculum, presubiculum, and CA1 pooled together) gave test-retest reproducibility similar to the whole hippocampus. Our findings suggest that the larger hippocampal subfields volume may be reliable longitudinal markers in multisite studies. Hum Brain Mapp 36:3516-3527, 2015. (c) 2015 Wiley Periodicals, Inc.

引用

页码：3516 / 3527

页数：12

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