BK polyomavirus: emerging pathogen

被引：78
作者：
Bennett, Shauna M. [1 ]
Broekema, Nicole M. [2 ]
Imperiale, Michael J. [1 ,2 ,3 ]
机构：
[1] Univ Michigan, Program Cellular & Mol Biol, Sch Med, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Microbiol & Immunol, Sch Med, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Ctr Comprehens Canc, Sch Med, Ann Arbor, MI 48109 USA
来源：
MICROBES AND INFECTION | 2012年 / 14卷 / 09期
关键词：
BKPyV; Polyomavirus; Transplantation; LARGE-T-ANTIGEN; NUCLEAR-PORE COMPLEX; VIRUS-INFECTION; RENAL-TRANSPLANTATION; RETINOBLASTOMA FAMILY; ENDOPLASMIC-RETICULUM; HEMORRHAGIC CYSTITIS; NATIVE KIDNEYS; CELL ENTRY; VIRAL LOAD;
D O I：
10.1016/j.micinf.2012.02.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
BK polyomavirus (BKPyV) is a small double-stranded DNA virus that is an emerging pathogen in immunocompromised individuals. BKPyV is widespread in the general population, but primarily causes disease when immune suppression leads to reactivation of latent virus. Polyomavirus-associated nephropathy and hemorrhagic cystitis in renal and bone marrow transplant patients, respectively, are the most common diseases associated with BKPyV reactivation and lytic infection. In this review, we discuss the clinical relevance, effects on the host, virus life cycle, and current treatment protocols. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：672 / 683
页数：12
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