Mixed-ligand platinum(IV) complexes with amino acids and cytosine

被引：6

作者：

Molodkin, A. K. ^{[1
]}

Esina, N. Ya. ^{[1
]}

Andreeva, O. I. ^{[1
]}

Konde, M. ^{[1
]}

机构：

[1] Russian Univ Peoples Friendship, Moscow 117198, Russia

来源：

RUSSIAN JOURNAL OF INORGANIC CHEMISTRY | 2008年 / 53卷 / 08期

关键词：

D O I：

10.1134/S0036023608080093

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Complex formation in platinum(IV)-cytosine-amino acid (glycine, alpha-alanine, lysine, or histidine) systems is studied using pH titration. Stability constants for 1 : 1 : 1 stoichiometry of complexes are determined. The stability of the mixed-ligand complexes varies in the following order: Lys < Ala < Gly < His. Reactions of aqueous solutions yields the following complexes: Pt(Cyt)(Gly(-))Cl-3 center dot 3H(2)O (I), Pt(Cyt)(Ala(-))Cl-3 center dot 3H(2)O (II), Pt(Cyt)(Hist)Cl-4 center dot 2H(2)O (III), and Pt(Cyt)(Lys)Cl-4 center dot 2H(2)O (IV). C-13 NMR, IR, and XPS spectra show that glycine and alanine are complexed via amino and carboxy groups, lysine via its alpha-amino group exclusively, and histidine via its amino group and heterocyclic N3 atom. Cytosine in these complexes is bidentate ( it is complexed via C=O oxygen and N3 heterocyclic atoms).

引用

页码：1203 / 1211

页数：9