p53AIP1 regulates the mitochondrial apoptotic pathway

被引：0
|
作者：
Matsuda, K
Yoshida, K
Taya, Y
Nakamura, K
Nakamura, Y
Arakawa, H
机构：
[1] Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab,Minato Ku, Tokyo 1088639, Japan
[2] Univ Tokyo, Fac Med, Dept Orthoped Surg, Bunkyo Ku, Tokyo 1130033, Japan
[3] Natl Canc Ctr, Res Inst, Chuo Ku, Tokyo 1040045, Japan
来源：
CANCER RESEARCH | 2002年 / 62卷 / 10期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We identified recently the p53AIP1 gene, a novel p53 target that mediates p53-dependent apoptosis. In the experiments reported here, ectopic expression of p53AIP1 induced down-regulation of mitochondrial DeltaPsim and release of cytochrome c from mitochondria in human cells. Immunoprecipitation and immunostaining experiments indicated interaction between p53AIP1 and bcl-2 proteins at mitochondria. Overexpression of bcl-2 blocked the down-regulation of mitochondrial DeltaPsim and the proapoptotic activity of p53AIP1. Our results implicate p53AIP1 as a pivotal mediator of the p53-dependent mitochondrial apoptotic pathway.
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收藏
页码：2883 / 2889
页数：7
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