Novel PET tracers: added value for endocrine disorders

被引：18

作者：

Bergeret, Sebastien ^{[1
]}

Charbit, Judith ^{[1
]}

Ansquer, Catherine ^{[2
,3
]}

Bera, Geraldine ^{[1
,4
]}

Chanson, Philippe ^{[5
,6
]}

Lussey-Lepoutre, Charlotte ^{[1
,7
]}

机构：

[1] Sorbonne Univ, Nucl Med Dept, Pitie Salpetriere Hosp, 47-83 Bd Hop, F-75013 Paris, France

[2] CHU Hotel Dieu, Nucl Med Dept, 1 Pl Alexis Ricordeau, F-44093 Nantes 1, France

[3] Angers Univ, CIRCINA INSERM, 8 Quai Moncousu, F-44000 Nantes, France

[4] Sorbonne Univ, LIB, INSERM U1146, Paris, France

[5] Hop Bicetre, AP HP, Serv Endocrinol & Malad Reprod, Ctr Reference Malad Rares Hypophyse, F-94275 Le Kremlin Bicetre, France

[6] Univ Paris Saclay, Univ Paris Sud, Fac Med Paris Sud, INSERM UMR S1185, F-94276 Le Kremlin Bicetre, France

[7] Georges Pompidou European Hosp, Cardiovasc Res Ctr, INSERM U970, 56 Rue Leblanc, F-75015 Paris, France

来源：

ENDOCRINE | 2019年 / 64卷 / 01期

关键词：

PET/CT; Neuroendocrine tumors; Primary hyperparathyroidism; 18F-Choline; 18F-FDOPA; Gallium-68; Somatostatin; 18F-FDG; POSITRON-EMISSION-TOMOGRAPHY; MEDULLARY-THYROID CARCINOMA; SOMATOSTATIN RECEPTOR SCINTIGRAPHY; GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS; FUNCTIONAL IMAGING MODALITIES; PRIMARY HYPERPARATHYROIDISM; F-18-DOPA PET; GA-68-DOTATATE PET/CT; PREOPERATIVE LOCALIZATION; PROGNOSTIC VALUE;

D O I：

10.1007/s12020-019-01895-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nuclear medicine has been implicated in the diagnosis and treatment of endocrine disorders for several decades. With recent development of PET tracers, functional imaging now plays a major role in endocrine tumors enabling with high performance to their localization, characterization, and staging. Besides F-18-FDG, which may be used in the management and follow-up of endocrine tumors, new tracers have emerged, such as F-18-DOPA for neuroendocrine tumors (NETs) (medullary thyroid carcinoma, pheochromocytomas and paragangliomas and well-differentiated NETs originating from the midgut) and F-18-Choline in the field of primary hyperparathyroidism. Moreover, some peptides such as somatostatin analogs can also be used for peptide receptor radionuclide therapy. In this context, Gallium-68 labeled somatostatin analogs (Ga-68-SSA) can help to tailor therapeutic choices and follow the response to treatment in the so-called theranostic approach. This review emphasizes the usefulness of these three novel PET tracers (F-18-Choline, F-18-FDOPA, and Ga-68-SSA) for primary hyperparathyroidism and neuroendocrine tumors.

引用

页码：14 / 30

页数：17

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