In-Stent Thrombosis after Antiplatelet Therapy Conversion while Awaiting Coronary Bypass

被引：0
作者：
Burke, Nathan [1 ]
Charlton, Tawanna [1 ]
Hawamdeh, Hussam [1 ]
Park, Ki [1 ]
机构：
[1] Univ Florida, Div Cardiovasc Med, Coll Med, Gainesville, FL 32610 USA
来源：
CARDIOVASCULAR INNOVATIONS AND APPLICATIONS | 2020年 / 5卷 / 02期
关键词：
Acute myocardial infarction/ST-elevation myocardial infarction; antiplatelet therapy; genetics; platelet biology; drug-eluting stem; drugs/pharmacotherapy; CLOPIDOGREL;
D O I：
10.15212/CVIA.2019.0589
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In-stent thrombosis (IST) is a rare yet dangerous complication that may occur despite optimized coronary intervention in the cardiac catheterization laboratory. This is a case of an 81-year-old man who presented with ST-elevation myocardial infarction. Right coronary artery (RCA) occlusion was suspected. RCA angiography and percutaneous coronary intervention were performed. Complicated left coronary artery disease was subsequently discovered. Per cardiothoracic surgeon request, the patient was transitioned from ticagrelor to clopidogrel therapy in preparation for coronary artery bypass grafting. The patient experienced IST the day before surgery while receiving clopidogrel. We examine this case, which highlights the complexity of antiplatelet therapy choice and the role of genetic testing in evaluation of IST risk.
引用
收藏
页码：139 / 143
页数：5
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  • [1] A Genotype-Guided Strategy for Oral P2Y12 Inhibitors in Primary PCI
    Claassens, Daniel M. F.
    Vos, Gerrit J. A.
    Bergmeijer, Thomas O.
    Hermanides, Renicus S.
    van 't Hof, Arnoud W. J.
    van der Harst, Pim
    Barbato, Emanuele
    Morisco, Carmine
    Gin, Richard M. Tjon Joe
    Asselbergs, Folkert W.
    Mosterd, Arend
    Herrman, Jean-Paul R.
    Dewilde, Willem J. M.
    Janssen, Paul W. A.
    Kelder, Johannes C.
    Postma, Maarten J.
    de Boer, Anthonius
    Boersma, Cornelis
    Deneer, Vera H. M.
    ten Berg, Jurrien M.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (17) : 1621 - 1631
  • [2] CYP2C19*2 and CYP2C9*3 alleles are associated with stent thrombosis: a case-control study
    Harmsze, Ankie M.
    van Werkum, Jochem W.
    ten Berg, Jurrien M.
    Zwart, Bastiaan
    Bouman, Heleen J.
    Breet, Nicoline J.
    van't Hof, Arnoud W. J.
    Ruven, Hendrik J. T.
    Hackeng, Christian M.
    Klungel, Olaf H.
    de Boer, Anthonius
    Deneer, Vera H. M.
    [J]. EUROPEAN HEART JOURNAL, 2010, 31 (24) : 3046 - 3053
  • [3] Reduced-Function CYP2C19 Genotype and Risk of Adverse Clinical Outcomes Among Patients Treated With Clopidogrel Predominantly for PCI A Meta-analysis
    Mega, Jessica L.
    Simon, Tabassome
    Collet, Jean-Philippe
    Anderson, Jeffrey L.
    Antman, Elliott M.
    Bliden, Kevin
    Cannon, Christopher P.
    Danchin, Nicolas
    Giusti, Betti
    Gurbel, Paul
    Horne, Benjamin D.
    Hulot, Jean-Sebastian
    Kastrati, Adnan
    Montalescot, Gilles
    Neumann, Franz-Josef
    Shen, Lei
    Sibbing, Dirk
    Steg, P. Gabriel
    Trenk, Dietmar
    Wiviott, Stephen D.
    Sabatine, Marc S.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 304 (16): : 1821 - 1830
  • [4] Updated Expert Consensus Statement on Platelet Function and Genetic Testing for Guiding P2Y12 Receptor Inhibitor Treatment in Percutaneous Coronary Intervention
    Sibbing, Dirk
    Aradi, Daniel
    Alexopoulos, Dimitrios
    ten Berg, Jurrien
    Bhatt, Deepak L.
    Bonello, Laurent
    Collet, Jean-Philippe
    Cuisset, Thomas
    Franchi, Francesco
    Gross, Lisa
    Gurbel, Paul
    Jeong, Young-Hoon
    Mehran, Roxana
    Moliterno, David J.
    Neumann, Franz-Josef
    Pereira, Naveen L.
    Price, Matthew J.
    Sabatine, Marc S.
    So, Derek Y. F.
    Stone, Gregg W.
    Storey, Robert F.
    Tantry, Udaya
    Trenk, Dietmar
    Valgimigli, Marco
    Waksman, Ron
    Angiolillo, Dominick J.
    [J]. JACC-CARDIOVASCULAR INTERVENTIONS, 2019, 12 (16) : 1521 - 1537
  • [5] Earlier recovery of platelet function after discontinuation of treatment with ticagrelor compared with clopidogrel in patients with high antiplatelet responses
    Storey, R. F.
    Bliden, K. P.
    Ecob, R.
    Karunakaran, A.
    Butler, K.
    Wei, C.
    Tantry, U.
    Gurbel, P. A.
    [J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011, 9 (09) : 1730 - 1737
  • [6] Predictors of Coronary Stent Thrombosis The Dutch Stent Thrombosis Registry
    van Werkum, Jochem W.
    Heestermans, Antonius A.
    Zomer, A. Carla
    Kelder, Johannes C.
    Suttorp, Maarten-Jan
    Rensing, Benno J.
    Koolen, Jacques J.
    Brueren, B. R. Guus
    Dambrink, Jan-Henk E.
    Hautvast, Raymond W.
    Verheugt, Freek W.
    ten Berg, Jurrien M.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 53 (16) : 1399 - 1409
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