Examination of Biologically Active Nanocomplexes by Nanoparticle Tracking Analysis

被引：22

作者：

Nikitin, Nikolai ^{[1
]}

Trifonova, Ekaterina ^{[1
]}

Karpova, Olga ^{[1
,3
]}

Atabekov, Joseph ^{[1
,2
,3
]}

机构：

[1] Moscow MV Lomonosov State Univ, Dept Virol, Moscow 119991, Russia

[2] Moscow MV Lomonosov State Univ, Belozersky Inst Physicochem Biol, Moscow 119991, Russia

[3] Sci & Potato Seed Producing Ctr, Moscow 143350, Russia

来源：

MICROSCOPY AND MICROANALYSIS | 2013年 / 19卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

nanoparticle tracking analysis; tobacco mosaic virus; spherical particles; biologically active nanocomplexes; TOBACCO-MOSAIC-VIRUS; PLANT-VIRUSES;

D O I：

10.1017/S1431927613000597

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Nanoparticle tracking analysis (NTA) was first applied to biologically active nanocomplexes to obtain concurrent information on their size, state of aggregation, concentration, and antigenic specificity in liquid. The subject of the NTA was an immunogenic complex (a candidate nanovaccine) comprised of spherical particles (SPs) generated by thermal remodeling of the tobacco mosaic virus and Rubella virus tetraepitopes exposed on the surface of SP.

引用

页码：808 / 813

页数：6

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