Universal influenza vaccines, science fiction or soon reality?

被引：22

作者：

de Vries, Rory D. ^{[1
]}

Altenburg, Arwen F. ^{[1
]}

Rimmelzwaan, Guus F. ^{[1
]}

机构：

[1] Erasmus MC, Dept Virosci, NL-3000 CA Rotterdam, Netherlands

来源：

EXPERT REVIEW OF VACCINES | 2015年 / 14卷 / 10期

基金：

欧洲研究理事会;

关键词：

immunity; influenza; universal; vaccine; virus; CROSS-REACT; A VIRUSES; T-CELLS; IMMUNOGENICITY; ECTODOMAIN; INFECTION;

D O I：

10.1586/14760584.2015.1060860

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Currently used influenza vaccines are only effective when the vaccine strains match the epidemic strains antigenically. To this end, seasonal influenza vaccines must be updated almost annually. Furthermore, seasonal influenza vaccines fail to afford protection against antigenically distinct pandemic influenza viruses. Because of an ever-present threat of the next influenza pandemic and the continuous emergence of drift variants of seasonal influenza A viruses, there is a need for an universal influenza vaccine that induces protective immunity against all influenza A viruses. Here, we summarize some of the efforts that are ongoing to develop universal influenza vaccines.

引用

页码：1299 / 1301

页数：3

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