Cross-priming versus cross-tolerance:: are two signals enough?

被引：26

作者：

Blankenstein, T

Schüler, T

机构：

[1] Free Univ Berlin, Inst Immunol, D-12200 Berlin, Germany

[2] Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany

来源：

TRENDS IN IMMUNOLOGY | 2002年 / 23卷 / 04期

关键词：

D O I：

10.1016/S1471-4906(02)02185-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Depending on their state of maturation, dendritic cells (DCs) can cross-prime or cross-tolerize T cells. Mature DCs provide T-cell-receptor ligands (signal 1) and costimulatory molecules (signal 2), and activate T cells. Immature DCs provide signal 1, but not signal 2, and tolerize T cells. However, new data show that it is not the expression of costimulatory molecules alone that determines whether DCs induce immunity or tolerance, because mature DCs can induce tolerance also.

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页码：171 / 173

页数：3

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