Stereoselective Pseudomonas cepacia lipase mediated synthesis of alpha-hydroxyamides

被引：16
作者：
Adamczyk, M
Grote, J
Rege, S
机构：
[1] Department of Chemistry (D9NM), Abbott Diagnostics Division, Abbott Laboratories, Abbott Park, IL
来源：
TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 15期
关键词：
D O I：
10.1016/S0957-4166(97)00270-X
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A new method for the synthesis of alpha-hydroxyamides via the Pseudomonas cepacia lipase catalyzed amidation of alpha-hydroxyesters in non-aqueous media is described. Reactivities of alpha-hydroxy benzyl esters are excellent, resulting in rapid conversions to good yields of alpha-hydroxyamides, while ethyl and methyl esters react more slowly, and some hindered esters show no reactivity under the conditions studied. Some benzyl esters react stereoselectively, producing excellent yields of asymmetric alpha-hydroxyamides. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：2509 / 2512
页数：4
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