CAR-T Cell Therapy - personalized cellular Immunotherapy in 2022

被引：0
|
作者：
Niebling, Janina [1 ]
Bethge, Wolfgang [2 ]
Lengerke, Claudia [3 ,4 ]
机构：
[1] Univ Klinikum Tubingen, Qualitatskontrolle Leukapherese Med Klin 2, Tubingen, Germany
[2] Univ Klinikum Tubingen, Zentrums Klin Studien, Tubingen, Germany
[3] Med Fak Tubingen, Tubingen, Germany
[4] Eberhard Karis Univ Tubingen, Humanmed, Tubingen, Germany
来源：
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT | 2022年 / 147卷 / 23期
关键词：
CAR T cells; chimeric antigen receptor T cells; real world data; registration studies;
D O I：
10.1055/a-1932-8145
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Chimeric antigen receptor T cells (CAR T cells) are genetically modified autologous or allogeneic T lymphocytes that target specific antigens and can be used, for example, to fight tumor cells. The registration studies show a high response and remission rate in massively pre-treated patients with aggressive B-cell lymphomas, acute lymphoblastic leukemia or multiple myeloma. The article presents the indications for approval, the clinical implementation and the management of side effects of CAR cell therapy.
引用
收藏
页码：1552 / 1561
页数：10
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