Design and synthesis of new antagonist peptides for platelet GPIIb/IIIa receptor as anti-thrombotic agents

被引：7

作者：

Hayashi, Y ^{[1
]}

Sato, Y ^{[1
]}

Katada, J ^{[1
]}

Takiguchi, Y ^{[1
]}

Ojima, I ^{[1
]}

Uno, I ^{[1
]}

机构：

[1] SUNY STONY BROOK, DEPT CHEM, STONY BROOK, NY 11794 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 12期

关键词：

D O I：

10.1016/0960-894X(96)00224-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The structure-activity relationships of N-terminal modified RGD peptides against platelet aggregation inhibitory activity were studied, and Orotyl-Ser-Arg-Gly-Asp-Trp (NSL-9403) was found to be a new and effective anti-thrombotic agent during extracorporeal circulation. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1351 / 1356

页数：6

共 20 条

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