Activity of the Oral Neuraminidase Inhibitor A-322278 against the Oseltamivir-Resistant H274Y (A/H1N1) Influenza Virus Mutant in Mice

被引：15
|
作者：
Baz, Mariana
Abed, Yacine
Nehme, Benjamin
Boivin, Guy [1 ]
机构：
[1] CHUL, CHUQ, Res Ctr Infect Dis, Ste Foy, PQ G1V 4G2, Canada
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 02期
关键词：
A-315675; INFECTION;
D O I：
10.1128/AAC.01276-08
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The new oral neuraminidase (NA) inhibitor A-322278 was evaluated in mice infected with influenza A/H1N1 wild-type virus or the oseltamivir-resistant (H274Y mutant) virus. A-322278 decreased mortality rates and lung virus titers significantly more than oseltamivir in mice infected with the NA H274Y mutant when therapy was started 4 h before or even 48 h after infection.
引用
收藏
页码：791 / 793
页数：3
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