Activity of the Oral Neuraminidase Inhibitor A-322278 against the Oseltamivir-Resistant H274Y (A/H1N1) Influenza Virus Mutant in Mice

被引：15
|
作者：
Baz, Mariana
Abed, Yacine
Nehme, Benjamin
Boivin, Guy [1 ]
机构：
[1] CHUL, CHUQ, Res Ctr Infect Dis, Ste Foy, PQ G1V 4G2, Canada
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 02期
关键词：
A-315675; INFECTION;
D O I：
10.1128/AAC.01276-08
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The new oral neuraminidase (NA) inhibitor A-322278 was evaluated in mice infected with influenza A/H1N1 wild-type virus or the oseltamivir-resistant (H274Y mutant) virus. A-322278 decreased mortality rates and lung virus titers significantly more than oseltamivir in mice infected with the NA H274Y mutant when therapy was started 4 h before or even 48 h after infection.
引用
收藏
页码：791 / 793
页数：3
相关论文
共 50 条
  • [1] In vitro activity of favipiravir and neuraminidase inhibitor combinations against oseltamivir-sensitive and oseltamivir-resistant pandemic influenza A (H1N1) virus
    Tarbet, E. Bart
    Vollmer, Almut H.
    Hurst, Brett L.
    Barnard, Dale L.
    Furuta, Yousuke
    Smee, Donald F.
    ARCHIVES OF VIROLOGY, 2014, 159 (06) : 1279 - 1291
  • [2] Enhanced Mammalian Transmissibility of Seasonal Influenza A/H1N1 Viruses Encoding an Oseltamivir-Resistant Neuraminidase
    Bouvier, Nicole M.
    Rahmat, Saad
    Pica, Natalie
    JOURNAL OF VIROLOGY, 2012, 86 (13) : 7268 - 7279
  • [3] Oseltamivir-Resistant Influenza A Pandemic (H1N1) 2009 Virus, Hong Kong, China
    Chen, Honglin
    Cheung, Chung Lam
    Tai, Hung
    Zhao, Pengxi
    Chan, Jasper F. W.
    Cheng, Vincent C. C.
    Chan, Kwok-Hung
    Yuen, Kwok-Yung
    EMERGING INFECTIOUS DISEASES, 2009, 15 (12) : 1970 - 1972
  • [4] Assessment of the efficacy of the neuraminidase inhibitor oseltamivir against 2009 pandemic H1N1 influenza virus in ferrets
    Govorkova, Elena A.
    Marathe, Bindumadhav M.
    Prevost, Ashley
    Rehg, Jerold E.
    Webster, Robert G.
    ANTIVIRAL RESEARCH, 2011, 91 (02) : 81 - 88
  • [5] Molecular dynamics study on the effect of the N1 neuraminidase double mutant G147R/H274Y on oseltamivir sensitivity
    Nurrohman, Ardiana Ilham
    Suwito, Hery
    Puspaningsih, Ni Nyoman Tri
    Ul Haq, Kautsar
    RSC ADVANCES, 2024, 14 (52) : 39017 - 39026
  • [6] Oseltamivir-Resistant Pandemic A/H1N1 Virus Is as Virulent as Its Wild-Type Counterpart in Mice and Ferrets
    Hamelin, Marie-Eve
    Baz, Mariana
    Abed, Yacine
    Couture, Christian
    Joubert, Philippe
    Beaulieu, Edith
    Bellerose, Nathalie
    Plante, Martin
    Mallett, Corey
    Schumer, Gregg
    Kobinger, Gary P.
    Boivin, Guy
    PLOS PATHOGENS, 2010, 6 (07) : 1 - 10
  • [7] Oseltamivir-resistant influenza A(H1N1)pdm09 virus associated with high case fatality, India 2015
    Tandel, Kundan
    Sharma, Shashi
    Dash, Paban Kumar
    Parida, ManMohan
    JOURNAL OF MEDICAL VIROLOGY, 2018, 90 (05) : 836 - 843
  • [8] Clinical Effectiveness of Oseltamivir and Zanamivir for Treatment of Influenza A Virus Subtype H1N1 with the H274Y Mutation: A Japanese, Multicenter Study of the 2007-2008 and 2008-2009 Influenza Seasons
    Kawai, Naoki
    Ikematsu, Hideyuki
    Hirotsu, Nobuo
    Maeda, Tetsunari
    Kawashima, Takashi
    Tanaka, Osame
    Yamauchi, Satoshi
    Kawamura, Kenichi
    Matsuura, Shinro
    Nishimura, Mika
    Iwaki, Norio
    Kashiwagi, Seizaburo
    CLINICAL INFECTIOUS DISEASES, 2009, 49 (12) : 1828 - 1835
  • [9] Evidence of Person-to-Person Transmission of Oseltamivir-Resistant Pandemic Influenza A(H1N1) 2009 Virus in a Hematology Unit
    Moore, Catherine
    Galiano, Monica
    Lackenby, Angie
    Abdelrahman, Tamer
    Barnes, Rosemary
    Evans, Meirion R.
    Fegan, Christopher
    Froude, Susannah
    Hastings, Mark
    Knapper, Steven
    Litt, Emma
    Price, Nicola
    Salmon, Roland
    Temple, Mark
    Davies, Eleri
    JOURNAL OF INFECTIOUS DISEASES, 2011, 203 (01) : 18 - 24
  • [10] Primarily oseltamivir-resistant influenza A (H1N1pdm09) virus evolving into a multidrug-resistant virus carrying H275Y and I223R neuraminidase substitutions
    Grund, Sebastian
    Gkioule, Charikleia
    Termos, Tahani
    Pfeifer, Nico
    Kobbe, Guido
    Verheyen, Jens
    Adams, Ortwin
    ANTIVIRAL THERAPY, 2015, 20 (01) : 97 - 100
12345