High Mean Corpuscular Volume Predicts Poor Outcome for Patients With Gastroesophageal Adenocarcinoma

被引：30

作者：

Jomrich, Gerd ^{[1
,2
]}

Hollenstein, Marlene ^{[1
,2
]}

John, Max ^{[1
,2
]}

Ristl, Robin ^{[3
]}

Paireder, Matthias ^{[1
,2
]}

Kristo, Ivan ^{[1
,2
]}

Asari, Reza ^{[1
,2
]}

Schoppmann, Sebastian F. ^{[1
,2
]}

机构：

[1] Med Univ Vienna, Dept Surg, Vienna, Austria

[2] CCC, Gastroesophageal Tumor Unit, Vienna, Austria

[3] Med Univ Vienna, Ctr Med Stat Informat & Intelligent Syst, Sect Med Stat IMS, Vienna, Austria

来源：

ANNALS OF SURGICAL ONCOLOGY | 2019年 / 26卷 / 04期

关键词：

SQUAMOUS-CELL CARCINOMA; PREOPERATIVE CHEMORADIOTHERAPY; NEOADJUVANT CHEMORADIOTHERAPY; ESOPHAGEAL ADENOCARCINOMA; HEMATOLOGY ANALYZER; PROGNOSTIC-FACTOR; SERUM-ALBUMIN; CANCER; ALCOHOL; CAPECITABINE;

D O I：

10.1245/s10434-019-07186-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundElevated mean corpuscular volume (MCV) is associated with a diminished prognosis for various tumor entities. This study aimed to evaluate the association between preoperative serum MCV levels and both overall (OS) and disease-free survival (DFS) for patients with resectable adenocarcinomas of the esophagogastric junction (AEG).MethodsThis study included consecutive patients undergoing surgical resection between 1992 and 2016. Measured preoperative MCV levels were stratified into quintiles and correlated with patients' survival and clinicopathologic characteristics. ResultsThe study analyzed 314 patients with a median OS of 36.8months and a median DFS of 20.6months. The multivariate analysis showed that preoperatively elevated MCV is a significant prognostic factor for OS (hazard ratio [HR], 1.05; 95% confidence interval [CI], 1.03-1.08; P<0.001) and DFS (HR, 1.05; 95% CI, 1.03-1.08; P<0.001). In the subgroup analysis of neoadjuvantly treated and untreated patients, MCV remained an independent prognostic factor for OS (HR, 1.08; 95% CI, 1.04-1.12; P<0.001) and DFS (HR, 1.07; 95% CI, 1.03-1.12; P<0.001) in both groups. In the univariate analysis, tumor stage and differentiation, adjuvant chemotherapy, MCV, mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were significantly correlated with diminished OS and DFS.ConclusionPreoperatively elevated MCV is an independent prognostic factor for patients with adenocarcinomas of the esophagus and the gastroesophageal junction.

引用

页码：976 / 985

页数：10

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