Integrated and translational nonclinical in vivo cardiovascular risk assessment: Gaps and opportunities

被引：12

作者：

Berridge, Brian R. ^{[1
]}

Hoffmann, Peter ^{[2
]}

Turk, James R. ^{[3
]}

Sellke, Frank ^{[4
]}

Gintant, Gary ^{[5
]}

Hirkaler, Gerald ^{[6
]}

Dreher, Kevin ^{[7
]}

Schultze, A. Eric ^{[8
]}

Walker, Dana ^{[9
]}

Edmunds, Nick ^{[10
]}

Halpern, Wendy ^{[11
]}

Falls, James ^{[1
]}

Sanders, Marty ^{[6
]}

Pettit, Syril D. ^{[12
]}

机构：

[1] GlaxoSmithKline, Res Triangle Pk, NC 27709 USA

[2] Novartis Pharmaceut, E Hanover, NJ 07936 USA

[3] Amgen Inc, Thousand Oaks, CA 91320 USA

[4] Brown Univ, Sch Med, Providence, RI 02903 USA

[5] Abbott Labs, Abbott Pk, IL 60064 USA

[6] Hoffman LaRoche, Nutley, NJ 07827 USA

[7] US EPA, Res Triangle Pk, NC 27709 USA

[8] Eli Lilly & Co, Greenfield, IN 46140 USA

[9] Bristol Myers Squibb Co, Wallingford, CT 06492 USA

[10] Pfizer Ltd, Sandwich CT13 9NJ, Kent, England

[11] Genentech Inc, San Francisco, CA 94080 USA

[12] HESI, Washington, DC 20005 USA

来源：

REGULATORY TOXICOLOGY AND PHARMACOLOGY | 2013年 / 65卷 / 01期

关键词：

Cardiotoxicity; Safety assessment; Nonclinical safety; Cardiovascular safety; ACUTE MYOCARDIAL-INFARCTION; FLOW-MEDIATED VASODILATION; QT INTERVAL PROLONGATION; INDUCED CARDIAC INJURY; ENDOTHELIAL FUNCTION; DIABETES-MELLITUS; HEART-FAILURE; SAFETY PHARMACOLOGY; NATRIURETIC-PEPTIDE; CLINICAL-TRIALS;

D O I：

10.1016/j.yrtph.2012.09.007

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Cardiovascular (CV) safety concerns are a significant source of drug development attrition in the pharmaceutical industry today. Though current nonclinical testing paradigms have largely prevented catastrophic CV events in Phase I studies, many challenges relating to the inability of current nonclinical safety testing strategies to model patient outcomes persist. Contemporary approaches include a spectrum of evaluations of CV structure and function in a variety of laboratory animal species. These approaches might be improved with a more holistic integration of these evaluations in repeat-dose studies, addition of novel endpoints with greater sensitivity and translational application, and use of more relevant animal models. Particular opportunities present with advances in imaging capabilities applicable to rodent and non-rodent species, technical capabilities for measuring CV function in repeat-dose animal studies, detection and quantitation of microRNAs and wider use of alternative animal models. Strategic application of these novel opportunities considering putative CV risk associated with the molecular drug target as well as inherent risks present in the target patient population could tailor or 'personalize' nonclinical safety assessment as a more translational evaluation. This paper is a call to action for the clinical and nonclinical drug safety communities to assess these opportunities to determine their utility in filling potential gaps in our current cardiovascular safety testing paradigms. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：38 / 46

页数：9

共 89 条

[31] Association of Serial Measures of Cardiac Troponin T Using a Sensitive Assay With Incident Heart Failure and Cardiovascular Mortality in Older Adults [J].