Pyrantel in small animal medicine: 30 years on

被引：25
作者：
Kopp, Steven R. [1 ]
Kotze, Andrew C. [2 ]
McCarthy, James S. [3 ]
Traub, Rebecca J. [1 ]
Coleman, Glen T. [1 ]
机构：
[1] Univ Queensland, Sch Vet Med, Brisbane, Qld 4072, Australia
[2] CSIRO Livestock Ind, Brisbane, Qld, Australia
[3] Joint Program Queensland Inst Med Res, Australian Ctr Trop & Int Hlth, Brisbane, Qld, Australia
来源：
VETERINARY JOURNAL | 2008年 / 178卷 / 02期
关键词：
Pyrantel; Dog; Cat; Ancylostoma; Resistance; Hookworm;
D O I：
10.1016/j.tvjl.2007.06.021
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Pyrantel, a tetrahydropyrimidine nicotinic agonist anthelmintic, has been used in companion animal medicine since the 1970s to control two important nematode groups, the hookworms and the roundworms. Given the zoonotic potential of these parasites, pyrantel has served a dual role in helping to protect the health of both companion animals and the public for more than 30 years. This review describes the history and mechanism of action of this drug, and collates evidence that resistance to pyrantel has developed in at least one canine nematode, the hookworm Ancylostoma caninum. The role of in vitro diagnosis tests in managing anthelmintic resistance in companion animal parasites is discussed, as are management practices that may reduce the rate at which resistance develops. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：177 / 184
页数：8
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