Cytotoxic flavonoids from the flowers of Achillea millefolium

被引：27

作者：

Huo, Chang-Hong ^{[1
]}

Li, Yong ^{[2
]}

Zhang, Man-Li ^{[1
]}

Wang, Yu-Fang ^{[1
]}

Zhang, Qing ^{[1
]}

Qin, Fang ^{[1
]}

Shi, Qing-Wen ^{[1
]}

Kiyota, Hiromasa ^{[3
]}

机构：

[1] Hebei Med Univ, Sch Pharmaceut Sci, Shijiazhuang, Hebei, Peoples R China

[2] Hebei Med Univ, Hebei Key Lab Forens Med, Shijiazhuang, Hebei, Peoples R China

[3] Tohoku Univ, Grad Sch Agr Sci, Sendai, Miyagi 980, Japan

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2013年 / 48卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Achillea millefolium; Compositae; flavonoids; antiproliferative activity; COMPOSITAE; SESQUITERPENOIDS; LACTONES; YARROW;

D O I：

10.1007/s10600-013-0438-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new natural product, 8,8'-bi-3-O-methylquercetin (9), and eight known flavonoids were isolated from the flowers of Achillea millefolium. Their structures were established on the basis of spectral evidence. All the spectral data of these compounds were reassigned after interpretation of their 2D NMR spectroscopic data. Compounds 2, 5, and 7 exhibited antiproliferative activity against human breast cancer cell line MCF7WT. In addition, 2 and 5 showed antiproliferative activity against human prostatic cancer cell line PC-3, while the other compounds did not show inhibitory effects in two human tumor cell lines tested.

引用

页码：958 / 962

页数：5

共 50 条

[41] Achillinin B and C, new sesquiterpene dimers isolated from Achillea millefolium
Li, Yong
Zhu, Meng-Chu
Zhang, Man-Li
Wang, Yu-Fang
Dong, Mei
Shi, Qing-Wen
Huo, Chang-Hong
Sauriol, Francoise
Kiyota, Hiromasa
Gu, Yu-Cheng
Cong, Bin
TETRAHEDRON LETTERS, 2012, 53 (21) : 2601 - 2603
[42] Betaines and free proline within the Achillea millefolium group
Mehlfuhrer, M
Troll, K
Jurenitsch, J
Auer, H
Kubelka, W
PHYTOCHEMISTRY, 1997, 44 (06) : 1067 - 1069
[43] Antispermatogenic effect of Achillea millefolium L. in mice
Montanari, T
de Carvalho, JE
Dolder, H
CONTRACEPTION, 1998, 58 (05) : 309 - 313
[44] In vitro antioxidant and antibabesial activities of the extracts of Achillea millefolium
Guz, L.
Adaszek, L.
Wawrzykowski, J.
Zietek, J.
Winiarczyk, S.
POLISH JOURNAL OF VETERINARY SCIENCES, 2019, 22 (02): : 369 - 376
[45] Phenolic compounds from Achillea millefolium L. and their bioactivity
Vitalini, Sara
Beretta, Giangiacomo
Iriti, Marcello
Orsenigo, Simone
Basilico, Nicoletta
Dall'Acqua, Stefano
Iorizzi, Maria
Fico, Gelsomina
ACTA BIOCHIMICA POLONICA, 2011, 58 (02) : 203 - 209
[46] ANTI-BIOFILM, ANTIMICROBIAL AND CYTOTOXIC ACTIVITY OF ACHILLEA MILLEFOLIUM L. ESSENTIAL OIL
Tutar, Ugur
FRESENIUS ENVIRONMENTAL BULLETIN, 2018, 27 (5A): : 3713 - 3720
[47] Three phenolic glycosides and immunological properties of Achillea millefolium from Iran, population of Golestan
Yassa, N.
Saeidnia, S.
Pirouzi, R.
Akbaripour, M.
Shafiee, A.
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES, 2007, 15 (01): : 49 - 52
[48] COMPOSITION OF THE ESSENTIAL OIL FROM CELL-SUSPENSION CULTURES OF ACHILLEA-MILLEFOLIUM SSP MILLEFOLIUM
FIGUEIREDO, AC
SALOME, M
PAIS, S
SCHEFFER, JJC
PLANT CELL TISSUE AND ORGAN CULTURE, 1995, 40 (02) : 113 - 118
[49] The effect of Achillea millefolium extract on spermatogenesis of male Wistar rats
Takzare, Nasrin
Hosseini, Mir-Jamal
Mortazavi, Seyedeh Hamideh
Safaie, Sahar
Moradi, Rayhaneh
HUMAN & EXPERIMENTAL TOXICOLOGY, 2011, 30 (04) : 328 - 334
[50] Beneficial effects of Achillea millefolium on skin injuries; a literature review
Dalili, Amin
Milani, Soheila Ebrahimnia
Kamali, Nasrin
Mohammadi, Sara
Pakbaz, Mehdi
Jamalnia, Sheida
Sadeghi, Mostafa
JOURNAL OF ESSENTIAL OIL RESEARCH, 2022, 34 (06) : 479 - 489

← 1 2 3 4 5 →