Cytotoxic flavonoids from the flowers of Achillea millefolium

被引：27

作者：

Huo, Chang-Hong ^{[1
]}

Li, Yong ^{[2
]}

Zhang, Man-Li ^{[1
]}

Wang, Yu-Fang ^{[1
]}

Zhang, Qing ^{[1
]}

Qin, Fang ^{[1
]}

Shi, Qing-Wen ^{[1
]}

Kiyota, Hiromasa ^{[3
]}

机构：

[1] Hebei Med Univ, Sch Pharmaceut Sci, Shijiazhuang, Hebei, Peoples R China

[2] Hebei Med Univ, Hebei Key Lab Forens Med, Shijiazhuang, Hebei, Peoples R China

[3] Tohoku Univ, Grad Sch Agr Sci, Sendai, Miyagi 980, Japan

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2013年 / 48卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Achillea millefolium; Compositae; flavonoids; antiproliferative activity; COMPOSITAE; SESQUITERPENOIDS; LACTONES; YARROW;

D O I：

10.1007/s10600-013-0438-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new natural product, 8,8'-bi-3-O-methylquercetin (9), and eight known flavonoids were isolated from the flowers of Achillea millefolium. Their structures were established on the basis of spectral evidence. All the spectral data of these compounds were reassigned after interpretation of their 2D NMR spectroscopic data. Compounds 2, 5, and 7 exhibited antiproliferative activity against human breast cancer cell line MCF7WT. In addition, 2 and 5 showed antiproliferative activity against human prostatic cancer cell line PC-3, while the other compounds did not show inhibitory effects in two human tumor cell lines tested.

引用

页码：958 / 962

页数：5

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