Genome-wide meta-analyses of smoking behaviors in African Americans

被引：79

作者：

David, S. P. ^{[1
,2
,3
]}

Hamidovic, A. ^{[4
]}

Chen, G. K. ^{[5
]}

Bergen, A. W. ^{[2
]}

Wessel, J. ^{[2
,6
,7
]}

Kasberger, J. L. ^{[8
]}

Brown, W. M. ^{[9
]}

Petruzella, S. ^{[10
]}

Thacker, E. L. ^{[11
]}

Kim, Y. ^{[12
]}

Nalls, M. A. ^{[13
]}

Tranah, G. J. ^{[14
]}

Sung, Y. J. ^{[15
]}

Ambrosone, C. B. ^{[16
]}

Arnett, D. ^{[17
]}

Bandera, E. V. ^{[18
]}

Becker, D. M. ^{[19
]}

Becker, L. ^{[19
]}

Berndt, S. I. ^{[20
]}

Bernstein, L. ^{[21
]}

Blot, W. J. ^{[22
,23
,24
]}

Broeckel, U. ^{[25
]}

Buxbaum, S. G. ^{[26
]}

Caporaso, N. ^{[20
]}

Casey, G. ^{[5
]}

Chanock, S. J. ^{[20
]}

Deming, S. L. ^{[23
,24
]}

Diver, W. R. ^{[27
]}

Eaton, C. B. ^{[3
]}

Evans, D. S. ^{[14
]}

Evans, M. K. ^{[28
]}

Fornage, M. ^{[29
]}

Franceschini, N. ^{[30
]}

Harris, T. B. ^{[31
]}

Henderson, B. E. ^{[5
]}

Hernandez, D. G. ^{[13
]}

Hitsman, B. ^{[4
]}

Hu, J. J. ^{[32
]}

Hunt, S. C. ^{[33
]}

Ingles, S. A. ^{[5
]}

John, E. M. ^{[34
,35
]}

Kittles, R. ^{[36
]}

Kolb, S. ^{[37
]}

Kolonel, L. N. ^{[38
]}

Le Marchand, L. ^{[38
]}

Liu, Y. ^{[39
]}

Lohman, K. K. ^{[9
]}

McKnight, B. ^{[40
]}

Millikan, R. C. ^{[41
]}

Murphy, A. ^{[42
]}

机构：

[1] Stanford Univ, Sch Med, Div Gen Med Disciplines, Ctr Educ & Res Family & Community Med, Stanford, CA 93405 USA

[2] SRI Int, Policy Div, Ctr Hlth Sci, Menlo Pk, CA 94025 USA

[3] Brown Alpert Med Sch, Ctr Primary Care & Prevent, Dept Family Med, Pawtucket, RI USA

[4] Northwestern Univ, Dept Preventat Med, Chicago, IL 60611 USA

[5] Univ So Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA

[6] Indiana Univ Sch Med, Div Epidemiol & Environm Hlth, Dept Publ Hlth, Indianapolis, IN USA

[7] Indiana Univ Sch Med, Div Cardiol, Dept Med, Indianapolis, IN USA

[8] Univ Calif San Francisco, Ernest Gallo Clin & Res Ctr, Dept Neurol, San Francisco, CA 94143 USA

[9] Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC USA

[10] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA

[11] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[12] NHGRI, Genometr Sect, NIH, Baltimore, MD USA

[13] NIA, Neurogenet Lab, NIH, Baltimore, MD 21224 USA

[14] Calif Pacific Med Ctr, Res Inst, San Francisco, CA USA

[15] Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA

[16] Roswell Pk Canc Inst, Dept Canc Prevent & Control, Buffalo, NY 14263 USA

[17] Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL USA

[18] Canc Inst New Jersey, New Brunswick, NJ USA

[19] Johns Hopkins Univ, Sch Med, Dept Med, Johns Hopkins GeneSTAR Res Program, Baltimore, MD 21205 USA

[20] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

[21] City Hope Natl Med Ctr, Beckman Res Inst, Div Canc Etiol, Dept Populat Sci, Duarte, CA 91010 USA

[22] Int Epidemiol Inst, Rockville, MD USA

[23] Vanderbilt Univ, Dept Med, Div Epidemiol, Vanderbilt Epidemiol Ctr, Nashville, TN USA

[24] Vanderbilt Ingram Canc Ctr, Nashville, TN USA

[25] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA

[26] Jackson State Univ, Jackson Heart Study, Jackson, MS USA

[27] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA

[28] NIA, Hlth Dispar Res Sect, Clin Res Branch, NIH, Baltimore, MD 21224 USA

[29] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Brown Fdn Inst Mol Med, Div Epidemiol, Houston, TX USA

[30] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA

[31] NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA

[32] Univ Miami, Miller Sch Med, Sylvester Comprehens Canc Ctr, Dept Epidemiol & Publ Hlth, Miami, FL 33136 USA

[33] Univ Utah, Dept Internal Med, Salt Lake City, UT 84112 USA

[34] Canc Prevent Inst Calif, Fremont, CA USA

[35] Stanford Univ, Sch Med, Stanford Canc Inst, Stanford, CA USA

[36] Univ Illinois, Sch Publ Hlth, Div Epidemiol & Biostat, Dept Med, Chicago, IL USA

[37] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA

[38] Univ Hawaii, Canc Res Ctr, Program Epidemiol, Honolulu, HI 96813 USA

[39] Wake Forest Univ, Sch Med, Sticht Ctr Aging, Winston Salem, NC 27109 USA

[40] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[41] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA

[42] Northwestern Univ, Dept Urol, Chicago, IL 60611 USA

[43] Henry Ford Hosp, Dept Publ Hlth Sci, Detroit, MI 48202 USA

[44] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[45] Univ Washington, Dept Med, Seattle, WA USA

[46] Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA

[47] Grp Hlth Cooperat Puget Sound, Grp Hlth Res Inst, Seattle, WA USA

[48] Harvard Univ, Sch Med, Dept Med, Boston, MA USA

[49] Harvard Univ, Sch Med, Div Sleep Med, Boston, MA USA

[50] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Psychiat,Ctr Human Genet Res, Boston, MA USA

来源：

TRANSLATIONAL PSYCHIATRY | 2012年 / 2卷

关键词：

African American; genome-wide association; health disparities; nicotine; smoking; tobacco; HAPLOTYPE-PHASE INFERENCE; NICOTINE DEPENDENCE; LUNG-CANCER; GENOTYPE IMPUTATION; BRONCHOPULMONARY DYSPLASIA; SUSCEPTIBILITY LOCUS; EUROPEAN-AMERICANS; RACIAL-DIFFERENCES; CIGARETTE-SMOKING; TWIN REGISTRY;

D O I：

10.1038/tp.2012.41

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The identification and exploration of genetic loci that influence smoking behaviors have been conducted primarily in populations of the European ancestry. Here we report results of the first genome-wide association study meta-analysis of smoking behavior in African Americans in the Study of Tobacco in Minority Populations Genetics Consortium (n = 32 389). We identified one non-coding single-nucleotide polymorphism (SNP; rs2036527[A]) on chromosome 15q25.1 associated with smoking quantity (cigarettes per day), which exceeded genome-wide significance (beta = 0.040, s.e. = 0.007, P = 1.84 x 10(-)8). This variant is present in the 5'-distal enhancer region of the CHRNA5 gene and defines the primary index signal reported in studies of the European ancestry. No other SNP reached genome-wide significance for smoking initiation (SI, ever vs never smoking), age of SI, or smoking cessation (SC, former vs current smoking). Informative associations that approached genome-wide significance included three modestly correlated variants, at 15q25.1 within PSMA4, CHRNA5 and CHRNA3 for smoking quantity, which are associated with a second signal previously reported in studies in European ancestry populations, and a signal represented by three SNPs in the SPOCK2 gene on chr10q22.1. The association at 15q25.1 confirms this region as an important susceptibility locus for smoking quantity in men and women of African ancestry. Larger studies will be needed to validate the suggestive loci that did not reach genome-wide significance and further elucidate the contribution of genetic variation to disparities in cigarette consumption, SC and smoking-attributable disease between African Americans and European Americans. Translational Psychiatry (2012) 2, e119; doi:10.1038/tp.2012.41; published online 22 May 2012

引用

页码：e119 / e119

页数：8

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