Trifluoromethylation of Allylsilanes under Photoredox Catalysis

被引：119

作者：

Mizuta, Satoshi ^{[1
]}

Engle, Keary M. ^{[1
]}

Verhoog, Stefan ^{[1
]}

Galicia-Lopez, Oscar ^{[1
]}

O'Duill, Miriam ^{[1
]}

Medebielle, Maurice ^{[2
]}

Wheelhouse, Katherine ^{[3
]}

Rassias, Gerasimos ^{[3
]}

Thompson, Amber L. ^{[1
]}

Gouverneur, Veronique ^{[1
]}

机构：

[1] Univ Oxford, Chem Res Lab, Oxford OX1 3TA, England

[2] Univ Lyon 1, F-69622 Villeurbanne, France

[3] GlaxoSmithKline Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 06期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

ORGANIC-SYNTHESIS; TERMINAL ALKENES; LIGHT; EFFICIENT; SILICON;

D O I：

10.1021/ol400184t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new catalytic method to access allylic secondary CF3 products is described. These reactions use the visible light excited Ru(bpy)(3)Cl-2 center dot 6H(2)O catalyst and the Togni or Umemoto reagent as the CF3 source. The photoredox catalytic manifold delivers enantioenriched allylic trifluoromethylated products not accessible under Cu(I) catalysis.

引用

收藏

页码：1250 / 1253

页数：4

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