Candida albicans Quorum Sensing Molecules Stimulate Mouse Macrophage Migration

被引:29
作者
Hargarten, Jessica C. [1 ]
Moore, Tyler C. [1 ]
Petro, Thomas M. [2 ]
Nickerson, Kenneth W. [1 ]
Atkin, Audrey L. [1 ]
机构
[1] Univ Nebraska, Sch Biol Sci, Lincoln, NE 68588 USA
[2] Univ Nebraska Med Ctr, Dept Oral Biol, Lincoln, NE USA
关键词
IMMUNE EVASION; MONOCYTE CHEMOATTRACTANT; WHITE; FARNESOL; INFECTIONS; INHIBITION; EXPRESSION; SURVIVAL; MODEL; YEAST;
D O I
10.1128/IAI.00886-15
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The polymorphic commensal fungus Candida albicans causes life-threatening disease via bloodstream and intra-abdominal infections in immunocompromised and transplant patients. Although host immune evasion is a common strategy used by successful human fungal pathogens, C. albicans provokes recognition by host immune cells less capable of destroying it. To accomplish this, C. albicans white cells secrete a low-molecular-weight chemoattractive stimulant(s) of macrophages, a phagocyte that they are able to survive within and eventually escape from. C. albicans opaque cells do not secrete this chemoattractive stimulant(s). We report here a physiological mechanism that contributes to the differences in the interaction of C. albicans white and opaque cells with macrophages. E,E-Farnesol, which is secreted by white cells only, is a potent stimulator of macrophage chemokinesis, whose activity is enhanced by yeast cell wall components and aromatic alcohols. E, E-farnesol results in up to an 8.5-fold increase in macrophage migration in vitro and promotes a 3-fold increase in the peritoneal infiltration of macrophages in vivo. Therefore, modulation of farnesol secretion to stimulate host immune recognition by macrophages may help explain why this commensal is such a successful pathogen.
引用
收藏
页码:3857 / 3864
页数:8
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