Prolinethiol Ether Catalysis in an Asymmetric Michael Reaction: Solvent-Free Synthesis of Functionalized Monohaloalkenes

被引：14

作者：

Xia, Ai-Bao ^{[1
]}

Wu, Chao ^{[1
]}

Xu, Dan-Qian ^{[1
]}

Wang, Yi-Feng ^{[1
]}

Du, Xiao-Hua ^{[1
]}

Li, Zhao-Bo ^{[2
]}

Xu, Zhen-Yuan ^{[1
]}

机构：

[1] Zhejiang Univ Technol, State Key Lab Breeding Base Green Chem Synth Tech, Hangzhou 310014, Zhejiang, Peoples R China

[2] Hangzhou Minsheng Pharmaceut Grp Co Ltd, Hangzhou 310014, Zhejiang, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 03期

基金：

中国国家自然科学基金;

关键词：

(E)-BETA-ARYL VINYL HALIDES; ONE-POT SYNTHESIS; ANTIVIRAL ACTIVITY; BIOLOGICAL EVALUATION; CYCLOHEXENONES; NITROOLEFINS; DERIVATIVES; ALDEHYDES; BROMIDES; KETONES;

D O I：

10.1021/jo302288z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The organocatalytic Michael reaction of ketones with gamma-monohalonitrodienes catalyzed by chiral prolinethiol ether under solvent-free conditions was developed. The described method represents a novel approach for accessing highly functionalized monohaloalkenes with alpha, beta-stereocenters of up to >99% ee.

引用

页码：1254 / 1259

页数：6

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