The significance of heat shock proteins in breast cancer therapy

被引：7

作者：

Halacli, Sevil Oskay ^{[1
]}

Halacli, Burcin ^{[1
]}

Altundag, Kadri ^{[1
]}

机构：

[1] Hacettepe Univ, Inst Canc, Dept Med Oncol, TR-06100 Ankara, Turkey

来源：

MEDICAL ONCOLOGY | 2013年 / 30卷 / 02期

关键词：

Heat shock proteins; Breast cancer; Treatment; DRUG-RESISTANCE; DOWN-REGULATION; DNA VACCINE; PHASE-II; HSP90; EXPRESSION; HSP27; GELDANAMYCIN; CELLS; 17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN;

D O I：

10.1007/s12032-013-0575-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The evalutionary conserved heat shock proteins are involved basically life protecting mechanisms against harmful extracellular effects such as primarily heat shock response. Normally, the expression of these proteins is increased for cellular adaptation to high temperature. This increase is also important in the etiology of breast cancer. Overexpression of heat shock proteins is associated with reduced disease-free survival in breast cancer. However, increased expression of these proteins is related to acquired resistance of traditional chemotherapeutic drugs in use in breast cancer treatment. In this review, we discuss the multiple roles of heatshock proteins in resistance and where we are to overcome this in clinical practice.

引用

页数：5

共 63 条

[1]

Antoon JW, 2012, AM J CANCER RES, V2, P446

[2] Population pharmacokinetic analysis of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in adult patients with solid tumors [J].