Improvement of chronic hepatitis B by iron chelation therapy in a patient with iron overload: A case report

被引：3
作者：
Zou, Dong-Mei [1 ]
Rong, Dong-Dong [2 ]
Zhao, Hong [1 ]
Su, Li [1 ]
Sun, Wan-Ling [1 ]
机构：
[1] Capital Med Univ, Xuanwu Hosp, Dept Hematol, 45 Changchun St, Beijing 100053, Peoples R China
[2] Capital Med Univ, Xuanwu Hosp, Dept Radiol, 45 Changchun St, Beijing 100053, Peoples R China
来源：
MEDICINE | 2017年 / 96卷 / 52期
关键词：
hepatitis B virus; iron chelation therapy; iron overload; THALASSEMIA MAJOR; VIRUS-INFECTION; HEPG2.2.15; CELLS; SURFACE-ANTIGEN; SERUM FERRITIN; LIVER IRON; METABOLISM; HEPCIDIN; DISEASE; HEART;
D O I：
10.1097/MD.0000000000009566
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Rationale:This report describes seroconversion of hepatitis B surface antigen (HBsAg) in a patient with marked iron overload caused by chronic hepatitis B (CHB) after receiving iron chelation therapy and discusses the role of iron chelation therapy in CHB.Patient concerns:Increased serum ferritin level for 2 months.Diagnosis:Secondary iron overload and CHB.Intervention:To relieve iron load of the body, the patient underwent regular phlebotomy therapy and deferoxamine (DFO) therapy. During the therapy, serum ferritin and hepatitis B virus (HBV) were monitored and the iron concentration of the liver and heart were followed by T2 of magnetic resonance imaging (MRI) scan.Outcomes:Serum ferritin gradually decreased. Approximately 1 year after the therapy, HBsAg turned persistently negative.Lessons:Iron chelation therapy may attenuate HBV infection.
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页数：4
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