Improvement of chronic hepatitis B by iron chelation therapy in a patient with iron overload: A case report

被引：3

作者：

Zou, Dong-Mei ^{[1
]}

Rong, Dong-Dong ^{[2
]}

Zhao, Hong ^{[1
]}

Su, Li ^{[1
]}

Sun, Wan-Ling ^{[1
]}

机构：

[1] Capital Med Univ, Xuanwu Hosp, Dept Hematol, 45 Changchun St, Beijing 100053, Peoples R China

[2] Capital Med Univ, Xuanwu Hosp, Dept Radiol, 45 Changchun St, Beijing 100053, Peoples R China

来源：

MEDICINE | 2017年 / 96卷 / 52期

关键词：

hepatitis B virus; iron chelation therapy; iron overload; THALASSEMIA MAJOR; VIRUS-INFECTION; HEPG2.2.15; CELLS; SURFACE-ANTIGEN; SERUM FERRITIN; LIVER IRON; METABOLISM; HEPCIDIN; DISEASE; HEART;

D O I：

10.1097/MD.0000000000009566

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rationale:This report describes seroconversion of hepatitis B surface antigen (HBsAg) in a patient with marked iron overload caused by chronic hepatitis B (CHB) after receiving iron chelation therapy and discusses the role of iron chelation therapy in CHB.Patient concerns:Increased serum ferritin level for 2 months.Diagnosis:Secondary iron overload and CHB.Intervention:To relieve iron load of the body, the patient underwent regular phlebotomy therapy and deferoxamine (DFO) therapy. During the therapy, serum ferritin and hepatitis B virus (HBV) were monitored and the iron concentration of the liver and heart were followed by T2 of magnetic resonance imaging (MRI) scan.Outcomes:Serum ferritin gradually decreased. Approximately 1 year after the therapy, HBsAg turned persistently negative.Lessons:Iron chelation therapy may attenuate HBV infection.

引用

页数：4

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