Akazamicin, a cytotoxic aromatic polyketide from marine-derived Nonomuraea sp.

被引：15

作者：

Yang, Taehui ^{[1
]}

Yamada, Katsuhisa ^{[2
]}

Zhou, Tao ^{[3
]}

Harunari, Enjuro ^{[3
]}

Igarashi, Yasuhiro ^{[3
]}

Terahara, Takeshi ^{[1
]}

Kobayashi, Takeshi ^{[1
]}

Imada, Chiaki ^{[1
]}

机构：

[1] Tokyo Univ Marine Sci & Technol, Grad Sch Marine Sci & Technol, Minato Ku, 4-5-7 Konan, Tokyo 1088477, Japan

[2] DHC Corp, Minato Ku, 2-7-1 Minami Azabu, Tokyo 1068571, Japan

[3] Toyama Prefectural Univ, Biotechnol Res Ctr, 5180 Kurokawa, Imizu, Toyama 9390398, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2019年 / 72卷 / 04期

关键词：

MICROMONOSPORA SP TP-A0316; TETROCARCIN CLASS; ANTIBIOTICS; KOSINOSTATIN; ARISOSTATINS; DISCOVERY; TAXONOMY; MEMBERS;

D O I：

10.1038/s41429-018-0139-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In our screening program on marine-derived actinomycetes, Nonomuraea sp. AKA32 isolated from deep-sea water collected from a depth of 800 m in Sagami Bay, Japan was found to produce compounds cytotoxic to cancer cells. Activity-guided purification led to the isolation of a new aromatic polyketide, akazamicin (1), along with two known compounds, actinofuranone C (2) and N-formylanthranilic acid (3). Structures of these compounds were elucidated through the interpretation of NMR and MS spectroscopic data. Compounds 1, 2, and 3 displayed cytotoxicity against murine B16 melanoma cell line with the IC50 value of 1.7, 1.2, and 25 mu M, respectively.

引用

页码：202 / 209

页数：8

共 29 条

[11] Statistical Research on the Bioactivity of New Marine Natural Products Discovered during the 28 Years from 1985 to 2012
Hu, Yiwen
Chen, Jiahui
Hu, Guping
Yu, Jianchen
Zhu, Xun
Lin, Yongcheng
Chen, Shengping
Yuan, Jie
[J]. MARINE DRUGS, 2015, 13 (01): : 202 - 221
[12] Revision of the structure assigned to the antibiotic BU-4664L from Micromonopora
Igarashi, Y
Miyanaga, S
Onaka, H
Takeshita, M
Furumai, T
[J]. JOURNAL OF ANTIBIOTICS, 2005, 58 (05) : 350 - 352
[13] NMR analysis of quinocycline antibiotics:: Structure determination of kosinostatin, an antitumor substance from Micromonospora sp TP-A0468
Igarashi, Y
Higuchi, H
Oki, T
Furumai, T
[J]. JOURNAL OF ANTIBIOTICS, 2002, 55 (02) : 134 - 140
[14] Arisostatins A and B, new members of tetrocarcin class of antibiotics from Micromonospora sp TP-A0316 -: II.: Structure determination
Igarashi, Y
Takagi, K
Kan, Y
Fujii, K
Harada, K
Furumai, T
Oki, T
[J]. JOURNAL OF ANTIBIOTICS, 2000, 53 (03) : 233 - 240
[15] Two butenolides with PPARα agonistic activity from a marine-derived Streptomyces
Igarashi, Yasuhiro
Ikeda, Marumi
Miyanaga, Satoshi
Kasai, Hiroaki
Shizuri, Yoshikazu
Matsuura, Nobuyasu
[J]. JOURNAL OF ANTIBIOTICS, 2015, 68 (05) : 345 - 347
[16] Imada C, 2013, MARINE MICROBIOLOGY: BIOACTIVE COMPOUNDS AND BIOTECHNOLOGICAL APPLICATIONS, P21
[17] Khanna M, 2011, INT J ADV BIOTECHNOL, V2, P357
[18] Madurahydroxylactone, an Inhibitor of Staphylococcus aureus FtsZ from Nonomuraea sp AN100570
Kim, Bo-Min
Choi, Ha-Young
Kim, Geon-Woo
Zheng, Chang-Ji
Kim, Young-Ho
Kim, Won-Gon
[J]. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2017, 27 (11) : 1994 - 1998
[19] Discovering new bioactive molecules from microbial sources
Monciardini, Paolo
Iorio, Marianna
Maffioli, Sonia
Sosio, Margherita
Donadio, Stefano
[J]. MICROBIAL BIOTECHNOLOGY, 2014, 7 (03): : 209 - 220
[20] Expanding our Understanding of Sequence-Function Relationships of Type II Polyketide Biosynthetic Gene Clusters: Bioinformatics-Guided Identification of Frankiamicin A from Frankia sp EAN1pec
Ogasawara, Yasushi
Yackley, Benjamin J.
Greenberg, Jacob A.
Rogelj, Snezna
Melancon, Charles E., III
[J]. PLOS ONE, 2015, 10 (04):

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