Akazamicin, a cytotoxic aromatic polyketide from marine-derived Nonomuraea sp.

被引：15

作者：

Yang, Taehui ^{[1
]}

Yamada, Katsuhisa ^{[2
]}

Zhou, Tao ^{[3
]}

Harunari, Enjuro ^{[3
]}

Igarashi, Yasuhiro ^{[3
]}

Terahara, Takeshi ^{[1
]}

Kobayashi, Takeshi ^{[1
]}

Imada, Chiaki ^{[1
]}

机构：

[1] Tokyo Univ Marine Sci & Technol, Grad Sch Marine Sci & Technol, Minato Ku, 4-5-7 Konan, Tokyo 1088477, Japan

[2] DHC Corp, Minato Ku, 2-7-1 Minami Azabu, Tokyo 1068571, Japan

[3] Toyama Prefectural Univ, Biotechnol Res Ctr, 5180 Kurokawa, Imizu, Toyama 9390398, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2019年 / 72卷 / 04期

关键词：

MICROMONOSPORA SP TP-A0316; TETROCARCIN CLASS; ANTIBIOTICS; KOSINOSTATIN; ARISOSTATINS; DISCOVERY; TAXONOMY; MEMBERS;

D O I：

10.1038/s41429-018-0139-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In our screening program on marine-derived actinomycetes, Nonomuraea sp. AKA32 isolated from deep-sea water collected from a depth of 800 m in Sagami Bay, Japan was found to produce compounds cytotoxic to cancer cells. Activity-guided purification led to the isolation of a new aromatic polyketide, akazamicin (1), along with two known compounds, actinofuranone C (2) and N-formylanthranilic acid (3). Structures of these compounds were elucidated through the interpretation of NMR and MS spectroscopic data. Compounds 1, 2, and 3 displayed cytotoxicity against murine B16 melanoma cell line with the IC50 value of 1.7, 1.2, and 25 mu M, respectively.

引用

页码：202 / 209

页数：8

共 29 条

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